Efficacy of assisted reproductive technology after ovarian tissue transplantation in a cohort of 11 patients with or without associated infertility factors,Journal of Assisted Reproduction and Genetics

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Efficacy of assisted reproductive technology after ovarian tissue transplantation in a cohort of 11 patients with or without associated infertility factors
Journal of Assisted Reproduction and Genetics ( IF 3.1 ) Pub Date : 2021-01-03 , DOI: 10.1007/s10815-020-02033-9
M Vatel ₁ , A Torre ₂ , B Paillusson ₃ , F Scheffler ₄ , M Bergere ₅ , M Benkhalifa _{6,

7} , M-T Le Martelot ₈ , F Leperlier ₉ , S Mirallié ₉ , L Selleret ₁₀ , M Prades-Borio ₁₁ , A Neuraz ₁₂ , V Barraud-Lange ₁₃ , N Boissel _{14,

15} , A Fortin ₁₆ , C Poirot _{14,

17}

Affiliation

Department of Reproductive Medicine, Clinique de la Muette, 75116, Paris, France.
Division of Child Health, Department of Obstetrics and Gynaecology, University of Nottingham, Nottingham, UK.
Department of Reproductive Medicine, Poissy Saint-Germain-en-Laye Hospital, 78300, Poissy, France.
Department of Reproductive Medicine, Amiens Hospital, 80054, Amiens, France.
Department of Reproductive Biology, Poissy Saint-Germain-en-Laye Hospital, 78300, Poissy, France.
Medicine and Reproductive Biology, University Hospital and School of Medicine, Picardy Jules Verne University, 80054, Amiens, France.
Peritox-INERIS, UMR-I 01, Joint Research Centre, Picardy Jules Verne University, 80054, Amiens, France.
Department of Reproductive Medicine, Brest Hospital, 29200, Brest, France.
Department of Reproductive Medicine and Biology, Nantes Hospital, 44000, Nantes, France.
Department of Gynecology and Obstetrics, Assistance Publique des Hôpitaux de Paris (AP-HP), Tenon Hospital, 75020, Paris, France.
Department of Reproductive Biology, Assistance Publique des Hôpitaux de Paris (AP-HP), Tenon Hospital, 75020, Paris, France.
Department of Gynecology and Obstetrics, Les Bluets Hospital, 75012, Paris, France.
Department of Reproductive Biology, Assistance Publique-Hôpitaux de Paris (AP-HP), Cochin Hospital, 75014, Paris, France.
Department of Hematology, Adolescents and Young Adults Unit, Fertility Preservation, Assistance Publique-Hôpitaux de Paris (AP-HP), Saint-Louis Hospital, 1 Avenue Claude Vellefaux, 75010, Paris, France.
Paris University, EA3518, 75006, Paris, France.
Department of Obstetrics and Gynecology, Assistance Publique des Hôpitaux de Paris (AP-HP), Pitié-Salpétrière Hospital, 75013, Paris, France.
Médecine Sorbonne University, 75005, Paris, France.

Purpose

IVF treatment in women with grafted frozen-thawed ovarian tissue is associated with poor reproductive outcomes. The aim of this study was to evaluate the efficacy of ovarian tissue transplantation (OTT) followed by assisted reproductive technology (ART) in women with or without associated infertility factors.

Methods

This is a prospective cohort study with retrospective data collection including eleven women, four of whom having an infertility factor (IF), who had undergone OTT in one university center between 2005 and 2017, followed by ART in six in vitro fertilization (IVF) centers.

Results

In total, 25 of the 85 cycles initiated (29%) were canceled, resulting in 60 oocyte retrievals. Ninety-five oocytes were retrieved: 36 were abnormal or immature, 29/39 fertilized (74%) after ICSI and 13/20 (65%) after IVF. Thirty-five embryos were transferred in seven patients (5/7 patients without IF and 2/4 patients with IF). After ART, one patient with IF experienced two pregnancies, one resulting in a live birth. For all patients, pregnancy rates and live birth rates were 7.4% and 3.7% per embryo transfer, respectively. Nine pregnancies and four live births occurred after spontaneous conception in five patients without IF, none in the infertility group.

Conclusion

This study confirms that IVF treatment in women with grafted frozen-thawed ovarian tissue is associated with poor outcomes. However, the chances of natural conception are high in women without IF. Patients with IF, without the possibility of spontaneous pregnancy, should be informed of poor reproductive outcomes after OTT followed by ART.

Trial registration number

NCT02184806

中文翻译：

卵巢组织移植后辅助生殖技术在 11 名有或无相关不孕因素患者的队列中的疗效

目的

移植冻融卵巢组织的女性的体外受精治疗与不良的生殖结果有关。本研究的目的是评估卵巢组织移植 (OTT) 和辅助生殖技术 (ART) 在有或没有相关不孕因素的女性中的疗效。

方法

这是一项具有回顾性数据收集的前瞻性队列研究，包括 11 名女性，其中 4 名患有不孕症 (IF)，她们于 2005 年至 2017 年期间在一个大学中心接受了 OTT，随后在六个体外受精 (IVF) 中心接受了 ART .

结果

总共开始的 85 个周期中有 25 个（29%）被取消，导致 60 个卵母细胞取回。回收了 95 个卵母细胞：36 个异常或未成熟，ICSI 后 29/39（74%）受精，IVF 后 13/20（65%）受精。7 名患者（5/7 名无 IF 患者和 2/4 名有 IF 患者）移植了 35 个胚胎。ART 后，一名患有 IF 的患者经历了两次怀孕，其中一名获得了活产。对于所有患者，每次胚胎移植的妊娠率和活产率分别为 7.4% 和 3.7%。5 名无 IF 的患者在自然受孕后发生 9 次妊娠和 4 次活产，不孕症组没有。