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Therapeutics and Vaccines: Strengthening Our Fight Against the Global Pandemic COVID-19
Current Microbiology ( IF 2.6 ) Pub Date : 2021-01-03 , DOI: 10.1007/s00284-020-02310-x
Arghyadeep Bhattacharjee 1 , Manish Saha 2 , Arpita Halder 1 , Arka Debnath 3 , Oindrilla Mukherjee 1
Affiliation  

The newly identified 2019 novel coronavirus (SARS-CoV-2) has become a public health concern globally posing a significant threat to human health and economy and creating an unprecedented crisis in all spheres of the global life. Emergence of new genotypes of SARS-CoV during the last few years has pointed out the limited efficacy of available vaccines and antivirals, constraining the global response to the COVID-19 outburst to largely monitoring/containment. There is high priority for treatment regimes and new potential therapeutic and vaccine strategies. Several candidates have shown promising outcomes in various in vitro and in vivo models. In addition, clinical trials are in progress to test conceivable therapies showing promising outcomes in various in vivo studies. Unfortunately, very little information is available in the scientific scope which offers details to the diverse strategies being targeted to fight the pandemic, particularly with respect to the molecular targets. This review article summarizes and highlights the ongoing advances and approaches that are being carried out across the globe in designing vaccines and novel therapeutics, with particular reference to the previous knowledge gained from other viral infections like with the earlier SARS and MERS-CoV. A detailed knowledge may pave the way to combat this pandemic COVID-19 as well as prevent similar deadly epidemics in future.

中文翻译:

治疗方法和疫苗:加强我们对抗全球流行病 COVID-19 的斗争

新发现的 2019 年新型冠状病毒(SARS-CoV-2)已成为全球公共卫生问题,对人类健康和经济构成重大威胁,并在全球生活的各个领域造成前所未有的危机。过去几年中 SARS-CoV 新基因型的出现表明现有疫苗和抗病毒药物的功效有限,限制了全球对 COVID-19 爆发的反应主要集中于监测/遏制。治疗方案和新的潜在治疗和疫苗策略具有高度优先权。一些候选药物已在各种体外和体内模型中显示出有希望的结果。此外,临床试验正在进行中,以测试可能的疗法,在各种体内研究中显示出有希望的结果。不幸的是,在科学范围内提供的信息很少,无法提供抗击这一流行病的各种策略的详细信息,特别是在分子靶标方面。这篇综述文章总结并强调了全球在设计疫苗和新型疗法方面正在取得的进展和方法,特别参考了之前从其他病毒感染(如早期的 SARS 和 MERS-CoV)中获得的知识。详细的了解可能会为抗击这种流行病(COVID-19)以及预防未来类似的致命流行病铺平道路。
更新日期:2021-01-03
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