Abstract The aim of this systematic review and meta-analysis was to pool the data on Single Nucleotide Polymorphisms (SNPs) in immune response genes associated with dental caries. Nineteen studies were included in the review and 18 in the meta-analysis. Twenty-two SNPs were evaluated, which are linked to six different genes (MBL2, LFT, MASP2, DEFB1, FCN2 and MUC5B). Most SNPs (81.8%) are related to the possible functional impact on protein coding. The MBL2 gene was associated with caries experience in the analysis of the homozygote (OR = 2.12 CI95%[1.12–3.99]) and heterozygote (OR = 2.22 CI95%[1.44–3.44]) genotypes. The MUC5B gene was associated according to an analysis of the heterozygous genotype (OR = 1.83 CI95%[1.08–3.09]). Thus, SNPs related to immune response genes are linked to the phenotype of caries experience. Although the meta-analysis showed that the genes MBL2 and MUC5B were associated with caries, these results should be interpreted with caution due to the quality of the evidence.

中文翻译：

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免疫反应和龋齿风险途径中的基因和 SNP：系统评价和荟萃分析

摘要 本系统评价和荟萃分析的目的是汇总与龋齿相关的免疫反应基因中单核苷酸多态性 (SNP) 的数据。19 项研究被纳入审查，18 项研究被纳入荟萃分析。评估了 22 个 SNP，它们与六个不同的基因（MBL2、LFT、MASP2、DEFB1、FCN2 和 MUC5B）相关。大多数 SNP (81.8%) 与可能对蛋白质编码的功能影响有关。MBL2 基因与纯合子 (OR = 2.12 CI95%[1.12–3.99]) 和杂合子 (OR = 2.22 CI95%[1.44–3.44]) 基因型分析中的龋齿经验相关。根据杂合基因型分析（OR = 1.83 CI95%[1.08–3.09]），MUC5B 基因相关。因此，与免疫反应基因相关的 SNP 与龋病经历的表型有关。