INTRODUCTION

Immunization by means of vaccination is a global health success story, saving millions of lives every year. In this regard, the epidemiology of measles, rabies, polio, rubella, varicella, influenza, and mumps infections, all of which can harm the nervous system, could be contained by global vaccination campaigns [1]. In addition, toxoid vaccines against bacterial toxins such as tetanus and diphtheria are indispensable and effective interventions for toxin-mediated neurologic diseases [1] The use of conjugate vaccines against major causes of bacterial meningitis (e.g., Haemophilus influenzae type b, Neisseria meningitidis, and Streptococcus pneumoniae) in routine pediatric immunization programs as well as for high-risk groups have significantly lowered the burden of disease over the past three decades [2] Immunization against measles is the only preventive measure against subacute sclerosing panencephalitis, a chronic progressive inflammatory disorder of the brain that is associated with a devastating course [3].

Prophylactic vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting coronavirus disease 2019 (COVID-19) is an eagerly awaited measure to contain the pandemic, which has had devastating medical, economic, and social consequences.

中文翻译：

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COVID-19 的一级预防：从神经学角度倡导疫苗接种

介绍

通过疫苗接种进行免疫是全球健康的成功故事，每年挽救数百万人的生命。在这方面，全球疫苗接种活动可以控制麻疹、狂犬病、脊髓灰质炎、风疹、水痘、流感和腮腺炎感染的流行病学，所有这些都会损害神经系统[ 1 ]。此外，对抗细菌毒素，如破伤风和白喉类毒素疫苗是毒素介导的神经系统疾病必不可少的，有效的干预[ 1 ]针对细菌性脑膜炎（例如，主要的原因，使用缀合疫苗的流感嗜血杆菌b型，脑膜炎奈瑟氏菌，和肺炎链球菌) 在过去的 30 年中，在常规儿科免疫计划中以及针对高危人群的免疫接种显着降低了疾病负担 [ 2 ] 麻疹免疫接种是预防亚急性硬化性全脑炎的唯一预防措施，亚急性硬化性全脑炎是一种慢性进行性脑炎性疾病这与毁灭性的过程有关 [ 3 ]。

针对严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 感染和由此产生的 2019 年冠状病毒病 (COVID-19) 进行预防性接种疫苗是一项备受期待的遏制大流行的措施，该大流行已造成毁灭性的医疗、经济和社会后果。