While the amide bond is one of the most widespread backbones in natural peptides, pharmaceuticals, and agrochemicals, the atom-economic synthesis of amides remains a major challenge in organic chemistry. In this context, transition-metal-catalyzed hydroaminocarbonylation of cost-effective alkenes and alkynes has emerged as an ideal approach to access amides. However, it is only in recent times that more chemo- and regioselective hydroaminocarbonylation transformations, covering large substrate scope and under milder conditions, have been reported. In this review, we highlight some recent contributions to this field and elucidate the impact of ligands on regioselectivity, as well as discuss the potential applications of abundantly available nitrogen sources for hydroaminocarbonylation.

尽管酰胺键是天然肽，药物和农用化学品中最广泛使用的主链之一，但酰胺的原子经济合成仍然是有机化学中的主要挑战。在这种情况下，过渡金属催化的具有成本效益的烯烃和炔烃的氢氨基羰基化已成为获取酰胺的理想方法。然而，直到最近，才报道了更多的化学和区域选择性的氢氨基羰基化转化，涵盖了较大的底物范围和在较温和的条件下。在这篇综述中，我们重点介绍了该领域的最新进展，阐明了配体对区域选择性的影响，并讨论了丰富的氮源在氢氨基羰基化中的潜在应用。