Magnetic Resonance Materials in Physics Biology and Medicine ( IF 2.3 ) Pub Date : 2021-01-02 , DOI: 10.1007/s10334-020-00896-8 Elora C Brenneman Wilson 1 , Anthony A Gatti 2, 3 , Monica R Maly 1, 2, 4
Objectives
When measuring changes in knee cartilage thickness in vivo after loading, mean values may not reflect local changes. The objectives of this investigation were: (1) use statistical parametric mapping (SPM) to determine regional deformation patterns of tibiofemoral cartilage in response to running; (2) quantify regional differences in cartilage thickness between males and females; and (3) explore the influence of sex on deformation.
Materials and methods
Asymptomatic males (n = 15) and females (n = 15) had MRI imaging of their right knee before and after 15 min of treadmill running. Medial and lateral tibial, and medial and lateral weight-bearing femoral cartilage were segmented. SPM was completed on cartilage thickness maps to test the main effects of Running and Sex, and their interaction. F-statistic maps were thresholded; clusters above this threshold indicated significant differences.
Results
Deformation was observed in all four compartments; the lateral tibia had the largest area of deformation (p < 0.0001). Thickness differences between sexes were observed in all four compartments, showing females have thinner cartilage (p ≤ 0.009). The lateral tibia had small clusters indicating an interaction of sex on deformation (p ≤ 0.012).
Discussion
SPM identified detailed spatial information on tibiofemoral cartilage thickness differences observed after running, and between sexes and their interaction.
中文翻译:
一种分区域评价跑步对膝关节软骨变形影响的新技术
目标
在测量加载后体内膝关节软骨厚度的变化时,平均值可能无法反映局部变化。本次调查的目的是:(1)使用统计参数映射(SPM)来确定胫股软骨响应跑步的区域变形模式;(2) 量化男性和女性软骨厚度的区域差异;(3) 探讨性别对变形的影响。
材料和方法
无症状男性 ( n = 15) 和女性 ( n = 15) 在跑步机跑步 15 分钟之前和之后对其右膝进行了 MRI 成像。内侧和外侧胫骨以及内侧和外侧负重股骨软骨被分割。SPM 在软骨厚度图上完成,以测试跑步和性行为的主要影响及其相互作用。F-统计图被阈值化;高于此阈值的集群表明存在显着差异。
结果
在所有四个隔室中都观察到了变形;外侧胫骨的变形面积最大(p < 0.0001)。在所有四个隔室中都观察到性别之间的厚度差异,表明女性的软骨更薄(p ≤ 0.009)。外侧胫骨有小簇,表明性别对变形的相互作用(p ≤ 0.012)。
讨论
SPM 确定了跑步后观察到的胫股软骨厚度差异的详细空间信息,以及两性之间及其相互作用。