Abstract

The aim of this study was to introduce new ionic liquid (IL)-based microemulsions and microemulgels as topical delivery systems for celecoxib. Ex-vivo diffusion of celecoxib loaded in IL-based microemulsions and microemulgels through the rat skin by using Franz diffusion cell was investigated and compared with traditional microemulsions. The investigated systems composed of the same nonionic surfactant/co-surfactant of tween-80/transcutol^®P, and different oil phases of [BMIM][PF₆], [OMIM][PF₆] and isopropyl myristate, for construction of ILs/W and O/W microemulsions. The particle size of the ILs/W and O/W microemulsion systems was determined by DLS method. The ex-vivo release results of ILs/W and O/W formulations, at similar conditions, showed that the celecoxib permeability of the ILs/W formulations is more than that of the O/W formulation, either as microemulsion or as microemulgel. As an interesting result, the celecoxib release percent and release rate from the ILs/W systems was more and faster than the O/W system. The kinetic mechanism for ILs/W systems had followed from first-order model and for O/W systems followed Higuchi zero-order model.

Graphic abstract

中文翻译：

---

离子液体基微乳剂和微乳剂中塞来昔布释放的离体评估，用于局部应用

摘要

这项研究的目的是引入新的基于离子液体（IL）的微乳剂和微乳剂作为塞来昔布的局部给药系统。使用Franz扩散池研究了载于IL基微乳和微乳中的塞来昔布在大鼠皮肤中的体外扩散，并将其与传统微乳进行了比较。相同的非离子表面活性/吐温-80的共表面活性剂组成/ TRANSCUTOL所研究的系统^® P，和[BMIM] [PF的不同油相₆ ]，[OMIM] [PF ₆）和肉豆蔻酸异丙酯，用于构建ILs / W和O / W微乳液。ILs / W和O / W微乳液体系的粒径通过DLS法测定。ILs / W和O / W制剂在类似条件下的离体释放结果表明，无论是微乳液还是微乳剂，ILs / W制剂的塞来昔布渗透性都比O / W制剂大。作为一个有趣的结果，塞来昔布的释放百分比和从ILs / W系统释放的速率比O / W系统更快。ILs / W系统的动力学机理遵循一阶模型，O / W系统的动力学机理遵循Higuchi零阶模型。

图形摘要