Psychiatric disorders such as schizophrenia can generate distress and disability along with heavy costs on individuals and health care systems. Different genetic and environmental factors play a pivotal role in the appearance of the mentioned disorders. Since the conventional treatment options for psychiatric disorders are suboptimal, investigators are trying to find novel strategies. Herein, stem cell therapies have been recommended as novel choices. In this context, the preclinical examination of stem cell-based therapies specifically using appropriate models can facilitate passing strong filters and serious examination to ensure proper quality and safety of them as a novel treatment approach. Animal models cannot be adequately helpful to follow pathophysiological features. Nowadays, stem cell-based models, particularly induced pluripotent stem cells reflected as suitable alternative models in this field. Accordingly, the importance of stem cell-based models, especially to experiment with the regenerative medicine outcomes for schizophrenia as one of the severe typing of psychiatric disorders, is addressed here.

精神分裂症等精神疾病会导致痛苦和残疾，同时给个人和医疗保健系统带来沉重的代价。不同的遗传和环境因素在上述疾病的出现中起着关键作用。由于精神疾病的传统治疗方案并不理想，研究人员正试图寻找新的策略。在此，干细胞疗法已被推荐为新选择。在这种情况下，专门使用适当模型对基于干细胞的疗法进行临床前检查可以促进通过强大的过滤器和认真的检查，以确保它们作为一种新的治疗方法的适当质量和安全性。动物模型不能充分帮助跟踪病理生理特征。如今，基于干细胞的模型，特别是诱导多能干细胞被反映为该领域合适的替代模型。因此，本文讨论了基于干细胞的模型的重要性，尤其是对精神分裂症作为严重的精神疾病类型之一的再生医学结果进行实验。