This study reports on the fabrication of biocompatible organic devices by means of inkjet printing with a novel combination of materials. The devices were fabricated on Parylene C (PaC), a biocompatible and flexible polymer substrate. The contact tracks were inkjet-printed using a silver nanoparticle ink, while the active sites were inkjet-printed using a poly (3,4ethylenedioxythiophene)/polystyrene sulfonate (PEDOT:PSS) solution. To insulate the final device, a polyimide ink was used to print a thick film, leaving small open windows upon the active sites. Electrical characterization of the final device revealed conductivities in the order of 10³ and 10² S.cm⁻¹ for Ag and PEDOT based inks, respectively. Cell adhesion assays performed with PC-12 cells after 96 h of culture, and B16F10 cells after 24 h of culture, demonstrated that the cells adhered on top of the inks and cell differentiation occurred, which indicates Polyimide and PEDOT:PSS inks are non-toxic to these cells. The results indicate that PaC, along with its surface-treated variants, is a potentially useful material for fabricating cell-based microdevices.

本研究报告了通过喷墨打印与新型材料组合制造生物相容性有机装置。这些设备是在聚对二甲苯 C (PaC) 上制造的，这是一种生物相容的柔性聚合物基板。接触轨迹使用银纳米粒子墨水进行喷墨印刷，而活性位点使用聚（3,4亚乙基二氧噻吩）/聚苯乙烯磺酸盐（PEDOT：PSS）溶液进行喷墨印刷。为了使最终设备绝缘，使用聚酰亚胺油墨印刷厚膜，在活动部位留下小的开放窗口。最终器件的电学特性揭示了大约 10 ³和 10 ²  S.cm ^{-1 的}电导率分别用于基于 Ag 和 PEDOT 的墨水。对培养 96 小时后的 PC-12 细胞和培养 24 小时后的 B16F10 细胞进行的细胞粘附测定表明，细胞粘附在墨水顶部并发生细胞分化，这表明聚酰亚胺和 PEDOT:PSS 墨水是非对这些细胞有毒。结果表明，PaC 及其表面处理过的变体是制造基于细胞的微型器件的潜在有用材料。