Indirect genetic effects from relatives may result in misleading quantifications of heritability, but can also be of interest in their own right. In this paper we propose Trio-GCTA, a model for separating direct and indirect genetic effects when genome-wide single nucleotide polymorphism data have been collected from parent-offspring trios. The model is applicable to phenotypes obtained from any of the family members. We discuss appropriate parameter interpretations and apply the method to three exemplar phenotypes: offspring birth weight, maternal relationship satisfaction, and paternal body-mass index, using real data from the Norwegian Mother, Father and Child Cohort Study (MoBa).

来自亲属的间接遗传效应可能会导致对遗传力的误导性量化，但它们本身也可能引起人们的兴趣。在本文中，我们提出了 Trio-GCTA，这是一个模型，用于在从亲代三人组收集全基因组单核苷酸多态性数据时分离直接和间接遗传效应。该模型适用于从任何家族成员获得的表型。我们使用来自挪威母亲、父亲和儿童队列研究 (MoBa) 的真实数据讨论了适当的参数解释并将该方法应用于三个示例表型：后代出生体重、母亲关系满意度和父亲体重指数。