We aimed to study the uptake of preexposure prophylaxis (PrEP) before and after its implementation in the Portuguese National Health Service (PNHS) among men who have sex with men (MSM). We studied 6164 participants in the Lisbon Cohort of MSM who participated between March 2014 and July 2019. 198 participants (3.2%) reported having recently used PrEP. Approximately one-third started PrEP after its implementation. PrEP uptake increased from 0.15% in 2014 to 5.36% in 2019. In their first use, 86 participants (70.5%) used it daily. How PrEP was obtained varied according to the timing of the first use: prescribed by a physician in Portugal (11.1% before vs 68.8% after implementation) and online (40.7% before vs 14.1% after). We observed an increase in the uptake and in the prescription by a physician, particularly after its implementation in the PNHS representing a change to a more equitable and safer way of using PrEP.

我们旨在研究男男性行为者 (MSM) 在葡萄牙国家卫生服务 (PNHS) 实施之前和之后对暴露前预防 (PrEP) 的吸收情况。我们研究了 2014 年 3 月至 2019 年 7 月期间参加的 MSM 里斯本队列中的 6164 名参与者。198 名参与者 (3.2%) 报告说最近使用过 PrEP。大约三分之一的人在实施后开始了 PrEP。PrEP 的使用率从 2014 年的 0.15% 增加到 2019 年的 5.36%。在首次使用时，86 名参与者 (70.5%) 每天都使用它。PrEP 的获得方式因首次使用的时间而异：由葡萄牙医生开处方（实施前 11.1% 对实施后 68.8%）和在线（实施前 40.7% 对实施后 14.1%）。我们观察到摄入量和医生处方的增加，