Breast cancer ranks among the most common cancers worldwide and can be lethal when not diagnosed early due to the high probability of metastasis. Herein a complementary metal-oxide-semiconductor (CMOS)-based capacitive nano-biosensor was developed to quickly and accurately quantify the concentration of an early-stage breast cancer diagnostic marker, microRNA-195, in blood. The microRNA probe was immobilized on optimized inter-digitated electrodes (IDE), and CMOS-sensing circuits detected the probe-analyte reaction at microRNA-195 concentrations as low as 0.617 fM. This high sensitivity could be due to the monolithically integrated nature of the circuits, for which “parasitic” effects on the capacitive sensors were markedly low. The CMOS-based capacitive nano-sensor may be promising for early diagnosis of breast cancer.

中文翻译：

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基于CMOS的电容式生物传感器，用于检测乳腺癌MicroRNA生物标志物。

乳腺癌是全球最常见的癌症之一，由于转移的可能性很高，因此如果不及早诊断，可能会致死。在本文中，开发了基于互补金属氧化物半导体（CMOS）的电容式纳米生物传感器，以快速，准确地量化血液中早期乳腺癌诊断标志物microRNA-195的浓度。将microRNA探针固定在优化的叉指电极（IDE）上，并且CMOS传感电路在microRNA-195浓度低至0.617 fM的情况下检测到探针-分析物反应。如此高的灵敏度可能是由于电路的单片集成特性，对于电容式传感器而言，其“寄生”效应非常低。基于CMOS的电容式纳米传感器对于乳腺癌的早期诊断可能很有希望。