As a transcription factor and proto-oncogene, MYC is known to be deregulated in a variety of tumors, including breast cancer. However, no consistent conclusion on the role and mechanism of MYC deregulation during breast cancer carcinogenesis has been formed. Here, we used the UALCAN, bc-GenExMiner, TCGA, cBioportal, STRING and Kaplan-Meier Plotter databases to explore the mRNA expression, prognosis, transcriptional profile changes, signal pathway rewiring and interaction with the cancer stem cells of MYC in breast cancer. We found that the expression of MYC varies in different subtypes of breast cancer, with relatively high frequency in TNBC. As a transcription factor, MYC not only participates in the rewiring of cancer signaling pathways, such as estrogen, WNT, NOTCH and other pathways, but also interacts with cancer stem cells. MYC is significantly positively correlated with breast cancer stem cell markers such as CD44, CD24, and ALDH1. Collectively, our results highlight that MYC plays an important regulatory role in the occurrence of breast cancer, and its amplification can be used as a predictor of diagnosis and prognosis. The interaction between MYC and cancer stem cells may play a crucial role in regulating the initiation and metastasis of breast cancer.

中文翻译：

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MYC功能障碍调节乳腺癌的干性和肿瘤发生

作为转录因子和原癌基因，已知 MYC 在包括乳腺癌在内的多种肿瘤中失调。然而，关于 MYC 失调在乳腺癌致癌过程中的作用和机制尚未形成一致的结论。在这里，我们使用 UALCAN、bc-GenExMiner、TCGA、cBioportal、STRING 和 Kaplan-Meier Plotter 数据库来探索乳腺癌中 MYC 的 mRNA 表达、预后、转录谱变化、信号通路重新布线以及与癌症干细胞的相互作用。我们发现 MYC 的表达在不同的乳腺癌亚型中存在差异，在 TNBC 中的表达频率相对较高。MYC作为一种转录因子，不仅参与癌症信号通路的重连，如雌激素、WNT、NOTCH等通路，还与癌症干细胞相互作用。MYC与CD44、CD24、ALDH1等乳腺癌干细胞标志物呈显着正相关。总的来说，我们的结果强调 MYC 在乳腺癌的发生中起着重要的调节作用，其扩增可作为诊断和预后的预测指标。MYC和癌症干细胞之间的相互作用可能在调节乳腺癌的发生和转移中起关键作用。