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Toward a unified analysis of cerebellum maturation and aging across the entire lifespan: A MRI analysis
Human Brain Mapping ( IF 4.8 ) Pub Date : 2021-01-01 , DOI: 10.1002/hbm.25293
José E Romero 1 , Pierrick Coupe 2, 3 , Enrique Lanuza 4 , Gwenaelle Catheline 3 , José V Manjón 1 ,
Affiliation  

Previous literature about the structural characterization of the human cerebellum is related to the context of a specific pathology or focused in a restricted age range. In fact, studies about the cerebellum maturation across the lifespan are scarce and most of them considered the cerebellum as a whole without investigating each lobule. This lack of study can be explained by the lack of both accurate segmentation methods and data availability. Fortunately, during the last years, several cerebellum segmentation methods have been developed and many databases comprising subjects of different ages have been made publically available. This fact opens an opportunity window to obtain a more extensive analysis of the cerebellum maturation and aging. In this study, we have used a recent state‐of‐the‐art cerebellum segmentation method called CERES and a large data set (N = 2,831 images) from healthy controls covering the entire lifespan to provide a model for 12 cerebellum structures (i.e., lobules I‐II, III, IV, VI, Crus I, Crus II, VIIB, VIIIA, VIIIB, IX, and X). We found that lobules have generally an evolution that follows a trajectory composed by a fast growth and a slow degeneration having sometimes a plateau for absolute volumes, and a decreasing tendency (faster in early ages) for normalized volumes. Special consideration is dedicated to Crus II, where slow degeneration appears to stabilize in elder ages for absolute volumes, and to lobule X, which does not present any fast growth during childhood in absolute volumes and shows a slow growth for normalized volumes.

中文翻译:

对整个生命周期中小脑成熟和衰老的统一分析:MRI 分析

以前关于人类小脑结构特征的文献与特定病理的背景有关或集中在有限的年龄范围内。事实上,关于整个生命周期小脑成熟的研究很少,他们中的大多数人认为小脑是一个整体,而没有研究每个小叶。缺乏研究可以解释为缺乏准确的分割方法和数据可用性。幸运的是,在过去的几年里,已经开发了几种小脑分割方法,并且公开了许多包含不同年龄受试者的数据库。这一事实打开了一个机会窗口,可以对小脑成熟和老化进行更广泛的分析。在这项研究中,Ñ = 2831倍的图像)从覆盖整个寿命为12层小脑结构(即提供一个模型健康对照小叶III,III,IV,VI,小腿I,II酒庄,VIIB,VIIIA,VIIIB,IX和X )。我们发现小叶的进化通常遵循由快速生长和缓慢退化组成的轨迹,有时绝对体积的平台,以及归一化体积的下降趋势(在早期更快)。特别考虑到 Crus II,其中缓慢退化似乎在老年时期的绝对体积稳定,小叶 X,绝对体积在儿童时期没有任何快速增长,并且显示出正常体积的缓慢增长。
更新日期:2021-03-03
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