Curcumin is a natural polyphenol obtained from Curcuma longa which has gained much attention in medical and scientific fields and is known for its wide range of therapeutic applications. But the natural herb mixtures with high subatomic sizes have low retention limits which does not permit the restorative medication to cross the lipid membranes, subsequently bringing about low bioavailability with confined proficiency. Nanobiotechnology has overcome the drawbacks of curcumin delivery to its targeted site through the use of antioxidant-rich, biodegradable SLNs as drug delivery vehicle with specificity and expanded bioavailability that will encourage the dynamic release of therapeutic ingredients into the body. Herein, optimized curcumin-loaded SLNs (CuSLNs) were developed. The morphological analysis of SEM has shown the average particle size was found to be in the range of 71–112 nm. The physicochemical characteristics of optimized CuSLNs were particle size of 106 nm, zeta potential of − 54 mV, polydispersity index of 0.429 which have confirmed the nanoparticle stability. The FTIR, DSC, and XRD results have suggested the lipids are compatible and confirmed the complete solubilization of curcumin in the lipid phase. Encapsulation efficiency and drug loading capacity of optimized formulation were 88.22 and 13.13, respectively. In vitro release studies have shown the controlled drug release rate of 88% compared with free curcumin and 81% of in vitro antioxidant activity which is compared with the ascorbic acid. The studies confirmed that the formulation of CuSLNs is a promising drug delivery system with controlled drug release, improved bioavailability with good stability.

中文翻译：

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用于姜黄素递送的富含 omega-3 的二元脂质载体的配方、优化和体外表征：持续释放及其潜在抗氧化行为的体外评估

姜黄素是一种从姜黄中提取的天然多酚，在医学和科学领域备受关注，并以其广泛的治疗应用而闻名。但是具有高亚原子尺寸的天然草药混合物具有较低的保留限制，这不允许恢复性药物穿过脂质膜，随后导致生物利用度低且熟练程度有限。纳米生物技术通过使用富含抗氧化剂、可生物降解的 SLN 作为药物递送载体，具有特异性和扩展的生物利用度，这将鼓励治疗成分动态释放到体内，从而克服了姜黄素递送到其目标部位的缺点。在此，开发了优化的加载姜黄素的 SLN（CuSLN）。SEM 的形态分析表明平均粒径在 71-112 nm 范围内。优化后的 CuSLN 的理化特性是粒径为 106 nm，zeta 电位为 - 54 mV，多分散指数为 0.429，这证实了纳米颗粒的稳定性。FTIR、DSC 和 XRD 结果表明脂质是相容的，并证实了姜黄素在脂质相中的完全溶解。优化配方的包封率和载药量分别为88.22和13.13。体外释放研究表明，与游离姜黄素相比，其受控药物释放率为 88%，与抗坏血酸相比，其体外抗氧化活性为 81%。