The scaffolds for skeletal muscle regeneration are designed to mimic the structure, stiffness, and strains applied to the muscle under physiologic conditions. The external strains are also used to stimulate myogenesis of the (stem) cells seeded on the scaffold. The time- and location-dependent mechanics inside the scaffold determine the microenvironment for the seeded cells. Here, fibrous-porous cylindrical scaffolds under the action of external cyclic strains are considered. The scaffold mechanics are described as two-phase (poroelastic) where the solid phase is associated with the fibers and the fluid phase is associated with the liquid-containing pores. In response to an applied cyclic strain, pressure oscillates and fluid moves radially toward and away from the axis of the scaffold. We compute the directions and magnitudes of the radial gradients of the poroelastic characteristics (solid-phase displacement, strain, and velocity; fluid-phase pressure and velocity; relative fluid-solid-phase velocity) determined by the boundary conditions and geometry of the scaffold. Several kinds of the external cyclic strain are analyzed and the resulting poroelastic functions are found. The poroelastic characteristics are obtained in closed form which is convenient for further consideration of myogenesis of the seeded cells and ultimately for the design of the scaffolds for skeletal muscle regeneration.

骨骼肌再生支架旨在模拟生理条件下施加到肌肉的结构、刚度和应变。外部菌株也用于刺激接种在支架上的（干）细胞的肌生成。支架内的时间和位置相关机制决定了种子细胞的微环境。在这里，考虑了外部循环应变作用下的纤维多孔圆柱形支架。支架力学被描述为两相（多孔弹性），其中固相与纤维相关，而流体相与含液体的孔隙相关。响应于施加的循环应变，压力发生振荡，流体朝向和远离支架的轴线径向移动。我们计算由支架的边界条件和几何形状确定的多孔弹性特征（固相位移、应变和速度；液相压力和速度；相对流固相速度）的径向梯度的方​​向和大小. 分析了几种外部循环应变，并找到了由此产生的多孔弹性函数。多孔弹性特性以封闭形式获得，便于进一步考虑接种细胞的肌生成，并最终设计用于骨骼肌再生的支架。分析了几种外部循环应变，并找到了由此产生的多孔弹性函数。多孔弹性特性以封闭形式获得，便于进一步考虑接种细胞的肌生成，并最终设计用于骨骼肌再生的支架。分析了几种外部循环应变，并找到了由此产生的多孔弹性函数。多孔弹性特性以封闭形式获得，便于进一步考虑接种细胞的肌生成，并最终设计用于骨骼肌再生的支架。