Mesenchymal stem cells, being characterized by high self-renewal capacity and multi-lineage differentiation potential, are widely used in regenerative medicine especially for repair of bone defects in patients with poor bone regenerative capacity. In this study, we aimed to compare the osteogenic potential of human maxillary schneiderian sinus membrane (hMSSM)-derived stem cells versus permanent teeth dental pulp stem cells (DPSCs). Both cells types were cultivated in osteogenic and non-osteogenic inductive media. Alkaline phosphatase (ALP) activity assay and quantitative real-time PCR analysis were carried out to assess osteogenic differentiation. We showed that ALP activity and osteoblastic markers transcription levels were more striking in hMSSM-derived stem cells than DPSCs. Our results highlight hMSSM-derived stem cells as a recommended stem cell type for usage during bone tissue regenerative therapy.

间充质干细胞具有较高的自我更新能力和多向分化潜能，被广泛应用于再生医学尤其是修复骨再生能力较差患者的骨缺损。在这项研究中，我们旨在比较人上颌施耐德窦膜 (hMSSM) 衍生的干细胞与恒牙牙髓干细胞 (DPSC) 的成骨潜力。两种细胞类型均在成骨和非成骨诱导培养基中培养。进行碱性磷酸酶 (ALP) 活性测定和定量实时 PCR 分析以评估成骨分化。我们发现，在 hMSSM 衍生的干细胞中，ALP 活性和成骨细胞标志物转录水平比 DPSCs 更显着。