Medicinal plants produce a diverse group of phytocompounds like anthraquinones, alkaloids, anthocyanins, flavonoids, saponins, and terpenes which are used in pharmaceutical, perfume, cosmetics, dye and flavor industries. Commercial source of these metabolites is field-grown plants, which are generally influenced by seasonal changes. Biotechnology possesses a significant role in production of high-value secondary metabolites. By incorporating biotechnological methods, it is feasible to manage biosynthetic pathways of the plant to enhance phytocompound production that is of pharmaceutical interest. Plant cell suspension, shoot, adventitious root and hairy root culture are considered as alternative methods for important bioactive compound production. These methods are controllable, sustainable and overcome several inconveniences for large scale secondary metabolites production. At present research on hairy root culture for valuable bioactive compound production has gained a lot of attention. Agrobacterium rhizogenes is an agent which causes hairy root disease in a plant and this leads to the neoplastic growth of root which is characterized by higher growth rate and genetic stability. Various studies explore the hairy root culture for production of a wide range of bioactive compounds. Scale-up of hairy root culture using bioreactors has provided an opportunity to enhance bioactive compound production at the commercial level. The present review discusses the role of hairy root culture in the production of valuable bioactive compounds, the effect of culture parameters on bioactive compound production and bioreactor applications.

药用植物产生多种植物化合物，如蒽醌，生物碱，花色苷，类黄酮，皂角苷和萜烯，用于制药，香水，化妆品，染料和调味品行业。这些代谢物的商业来源是田间生长的植物，通常受季节变化的影响。生物技术在高价值次级代谢产物的生产中具有重要作用。通过结合生物技术方法，管理植物的生物合成途径以增强具有药用价值的植物化合物的生产是可行的。植物细胞悬浮，芽，不定根和毛状根培养被认为是重要的生物活性化合物生产的替代方法。这些方法是可控的 可持续，并克服了大规模次级代谢产物生产的诸多不便。目前，关于毛状根培养用于有价值的生物活性化合物生产的研究已引起广泛关注。发根农杆菌是引起植物毛状根病的试剂，其导致根的赘生性生长，其特征在于更高的生长速率和遗传稳定性。各种研究探索了毛状根培养物，以生产多种生物活性化合物。使用生物反应器扩大毛状根培养物的规模提供了在商业水平上增强生物活性化合物生产的机会。本综述讨论了毛状根培养物在有价值的生物活性化合物生产中的作用，