It is important to evaluate the mechanical biocompatibility of nanofibrous membranes used in tissue engineering. This investigation proposed a modeling analysis to predict the biaxial behavior of randomly oriented nanofibrous membranes. An electrospinning process prepared poly(ε-caprolactone) nanofibers. The uniaxial stress–strain curve of a single nanofiber and the biaxial stress–strain curves of the membranes were experimentally obtained. The applicability of the analytical model was verified by the comparison between modeling prediction and experimental data. Experimental stress was lower than the predicted stress until large plastic deformation occurred because of structural imperfections, prestress, and the stretch-induced orientation in the membranes.

中文翻译：

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纳米纤维膜双轴拉伸的力学关系模型

评估用于组织工程的纳米纤维膜的机械生物相容性很重要。这项研究提出了一种模型分析，以预测随机取向的纳米纤维膜的双轴行为。电纺丝工艺制备了聚（ε-己内酯）纳米纤维。通过实验获得了单根纳米纤维的单轴应力-应变曲线和膜的双轴应力-应变曲线。通过模型预测和实验数据的比较，验证了该分析模型的适用性。由于结构缺陷，预应力和拉伸引起的膜取向，实验应力一直低于预计应力，直到发生大的塑性变形。