ABSTRACT

Objective

In healthy subjects, there is a reduction in the amplitudes of somatosensory-evoked potentials (SEPs) after the simultaneous stimulation of two nerves compared to the sum of separate stimulations. This reduction is due to the inhibition of one area in the cortex after stimulation of the neighboring area, which results from the surround inhibition (SI) phenomenon. In this study, we aimed to investigate whether there was a decrease in SI of SEP in patients with juvenile myoclonic epilepsy (JME).

Methods

We included 17 patients with JME and 18 healthy subjects. Groups were similar in terms of age and gender. We recorded SEPs after stimulating (i) median nerve (mSEP), (ii) ulnar nerve (uSEP), (iii) median and ulnar nerves simultaneously (muSEP) at wrist. The arithmetic sum (aSEP) of amplitudes of mSEP and uSEP was compared with the amplitudes of muSEP. We also calculated SI%.

Results

The amplitudes of SEPs were significantly higher in the JME group than in the healthy subjects (mSEP, p = 0.005; uSEP, p = 0.032; muSEP, p = 0.014). In healthy subjects and the JME group, the amplitude of muSEP was significantly lower than the aSEP (p = 0.014; p = 0.001, respectively). However, SI% was significantly higher in the JME group (p = 0.010).

Significance

Although the SI is maintained in JME patients, the higher SI% indicates an impairment relative to healthy subjects.

中文翻译：

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青少年肌阵挛性癫痫患者的周围抑制

摘要

客观的

在健康受试者中，与单独刺激的总和相比，同时刺激两条神经后，体感诱发电位 (SEP) 的幅度会降低。这种减少是由于刺激邻近区域后皮质中的一个区域受到抑制，这是由环绕抑制 (SI) 现象引起的。在本研究中，我们旨在调查青少年肌阵挛性癫痫 (JME) 患者的 SEP 的 SI 是否降低。

方法

我们纳入了 17 名 JME 患者和 18 名健康受试者。各组在年龄和性别方面相似。我们在腕部同时刺激 (i) 正中神经 (mSEP)、(ii) 尺神经 (uSEP)、(iii) 正中神经和尺神经 (muSEP) 后记录了 SEP。将 mSEP 和 uSEP 幅度的算术和 (aSEP) 与 muSEP 幅度进行比较。我们还计算了 SI%。

结果

JME 组的 SEP 幅度显着高于健康受试者（mSEP，p = 0.005；uSEP，p = 0.032；muSEP，p = 0.014）。在健康受试者和 JME 组中，muSEP 的幅度显着低于 aSEP（分别为p = 0.014；p = 0.001）。然而，JME 组的 SI% 显着更高（p = 0.010）。

意义

尽管 JME 患者的 SI 保持不变，但较高的 SI% 表明相对于健康受试者存在损伤。