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Current understanding and controversies on the clinical implications of fibroblast growth factor 21
Critical Reviews in Clinical Laboratory Sciences ( IF 10.0 ) Pub Date : 2020-12-31 , DOI: 10.1080/10408363.2020.1864278
Yasaman Badakhshi 1, 2, 3 , Tianru Jin 1, 2, 3
Affiliation  

Abstract

Metabolic functions of the hepatic hormone fibroblast growth factor 21 (FGF21) have been recognized for more than a decade in studying the responses of human subjects and rodent models to nutritional stresses such as fasting, high-fat diet or ketogenic diet consumption, and ethanol intake. Our interest in the beneficial metabolic effects of FGF21 has risen due to its potential ability to serve as a therapeutic agent for various metabolic disorders, including type 2 diabetes, obesity, and fatty liver diseases, as well as its potential to act as a diagnostic or prognostic biomarker for metabolic and other disorders. Here, we briefly review the FGF21 gene and protein structures, its expression pattern, and cellular signaling cascades that mediate FGF21 production and function. We mainly focus on discussing experimental and clinical literature pertaining to FGF21 as a therapeutic agent. Furthermore, we present several lines of investigation, including a few studies conducted by our team, suggesting that FGF21 expression and function can be regulated by dietary polyphenol interventions. Finally, we discuss the literature debating FGF21 as a potential biomarker in various disorders.



中文翻译:

目前对成纤维细胞生长因子 21 临床意义的理解和争议

摘要

十多年来,肝脏激素成纤维细胞生长因子 21 (FGF21) 的代谢功能在研究人类受试者和啮齿动物模型对营养应激(如禁食、高脂肪饮食或生酮饮食消耗以及乙醇摄入)的反应中得到认可. 我们对 FGF21 有益代谢作用的兴趣已经上升,因为它具有作为各种代谢紊乱(包括 2 型糖尿病、肥胖症和脂肪肝疾病)治疗剂的潜力,以及它作为诊断或治疗的潜力。代谢和其他疾病的预后生物标志物。在这里,我们简要回顾了 FGF21 基因和蛋白质结构、其表达模式以及介导 FGF21 产生和功能的细胞信号级联。我们主要讨论有关 FGF21 作为治疗剂的实验和临床文献。此外,我们提出了几项研究,包括我们团队进行的一些研究,表明 FGF21 的表达和功能可以通过膳食多酚干预进行调节。最后,我们讨论了辩论 FGF21 作为各种疾病的潜在生物标志物的文献。

更新日期:2020-12-31
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