Quinolones are a family of antibiotics containing a bicyclic core structure related to the compound 4-quinolone and have presented an increased use because of their high potency, broad spectrum of activity, convenient formulations, as well as a comparatively low incidence of side effects.1,2,3 However, quinolones are the second most common antibiotic class associated with drug hypersensitivity reactions (DHR)3 , being the fourth cause of consultations due to suspected drug allergy in Spain, and showing an increased incidence in the last years (4.3% of consultations in 2015 vs 1% in 1992).4.

中文翻译：

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嗜碱性粒细胞活化试验在喹诺酮类过敏反应诊断中的应用

喹诺酮类抗生素是一类含有与化合物 4-喹诺酮相关的双环核心结构的抗生素，由于其高效力、广谱活性、方便的配方以及相对较低的副作用发生率，其用途越来越广。 1 ,2,3 然而，喹诺酮类药物是与药物超敏反应 (DHR)3 相关的第二大常见抗生素类别，是西班牙因疑似药物过敏而进行咨询的第四大原因，并且在过去几年中发病率有所增加（4.3% 2015 年的咨询数量 vs 1992 年的 1%).4.