Diclofenac is a non-steroidal anti-inflammatory drug of wide use around the world for the treatment of several diseases such as ankylosing spondylitis, acute muscle pain conditions, and osteoarthritis. Although in proper doses it does not display any side effects, an overdose of diclofenac can cause adverse effects in the human body. Moreover, the presence of diclofenac in ecosystems directly affects the health of living organisms, even if it is present at trace. Therefore, the development of analytical tools for diclofenac monitoring was needed. In this context, electrochemical sensing and biosensing methods have been commonly reported. In this review, a critical evaluation of the methods employed for diclofenac analysis is presented according to the following classifications: potentiometric sensors, sensing at non-modified solid electrodes, chemically modified electrodes and biosensors. Recent developments related to the use of electrochemical detection of diclofenac in pharmaceutical formulations, biological fluids and environmental samples were reported and discussed.

双氯芬酸是一种非甾体类抗炎药，在世界范围内广泛用于治疗多种疾病，例如强直性脊柱炎，急性肌肉疼痛和骨关节炎。尽管以适当的剂量不会显示任何副作用，但双氯芬酸的过量使用会对人体产生不利影响。此外，双氯芬酸在生态系统中的存在会直接影响活生物体的健康，即使其存在的可能性很小。因此，需要开发用于双氯芬酸监测的分析工具。在这种情况下，通常已经报道了电化学传感和生物传感方法。在本综述中，根据以下分类对双氯芬酸分析所用方法进行了严格评估：电位传感器，未修饰固体电极上的感测，化学修饰的电极和生物传感器。报告和讨论了有关在药物制剂，生物流体和环境样品中双氯芬酸的电化学检测的使用的最新进展。