Anhedonia is a core symptom of major depressive disorder (MDD). Two subtypes of anhedonia: anticipatory anhedonia and consummatory anhedonia has been recognized in MDD patients. However, our knowledge regarding the distinction of anticipatory anhedonia and consummatory anhedonia in MDD remains limited. This study aimed to characterize the anticipatory anhedonia and consummatory anhedonia in first-episode, drug-naïve MDD patients. Resting-state functional MRI and T1-structural MRI were acquired for 38 MDD patients and 65 matched healthy controls (HCs). The ALFF and cortical surface indexes were compared between MDD and HCs. Then the correlations between the ALFF and cortical surface indexes alternations and the scores of anticipatory and consummatory pleasure measured by Temporal Experience of Pleasure Scale were evaluated. The elevated ALFF of left dorsal anterior cingulate cortex (dACC) and the reduced cortical thickness (CT) of left rostral ACC and lateral orbitofrontal cortex (lOFC) were respectively correlated with anticipatory anhedonia and consummatory anhedonia in MDD patients. These findings suggested the dissociated pathophysiological basis and imaging characteristics of anticipatory anhedonia and consummatory anhedonia. The ALFF and CT values of ACC and lOFC might serve as the imaging biomarker of the subtypes of anhedonia in early onset of MDD.

中文翻译：

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表征重度抑郁症快感缺乏亚型：症状特异性多模式 MRI 研究

快感缺失是重度抑郁症 (MDD) 的核心症状。快感缺乏症的两种亚型：预期性快感缺乏症和完成性快感缺乏症已在 MDD 患者中得到认可。然而，我们对 MDD 中预期性快感缺乏和完成性快感缺乏的区别的了解仍然有限。本研究旨在表征初发、未接受药物治疗的 MDD 患者的预期性快感缺乏和完成性快感缺乏。对 38 名 MDD 患者和 65 名匹配的健康对照 (HC) 进行了静息状态功能 MRI 和 T1 结构 MRI。比较 MDD 和 HC 之间的 ALFF 和皮质表面指数。然后评估 ALFF 和皮层表面指数变化与由时间快乐体验量表测量的预期和完成性快乐得分之间的相关性。MDD患者左背侧前扣带回皮层（dACC）的ALFF升高以及左侧额侧ACC和外侧眶额皮层（lOFC）的皮质厚度（CT）降低分别与预期性快感缺乏和完成性快感缺乏相关。这些发现表明预期性快感缺乏和完成性快感缺乏的分离病理生理学基础和影像学特征。ACC和lOFC的ALFF和CT值可能作为MDD发病早期快感缺乏亚型的影像标志物。这些发现表明预期性快感缺乏和完成性快感缺乏的分离病理生理学基础和影像学特征。ACC和lOFC的ALFF和CT值可能作为MDD发病早期快感缺乏亚型的影像标志物。这些发现表明预期性快感缺乏和完成性快感缺乏的分离病理生理学基础和影像学特征。ACC和lOFC的ALFF和CT值可能作为MDD发病早期快感缺乏亚型的影像标志物。