Mas-related G protein-coupled receptors (Mrgprs) are a family of receptors implicated in a diverse array of human diseases. Since their discovery in 2001, great progress has been made in determining their relation to human disease. Vital for Mrgprs therapeutic efforts across all disease disciplines is a thorough understanding of Mrgprs signal transduction pathways and polymorphisms, as these offer insights into new drug candidates, existing discrepancies in drug response, and differences in disease susceptibility. In this review, we discuss the current state of knowledge regarding Mrgprs signaling pathways and polymorphisms.

中文翻译：

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Mrgprs的信号通路和多态性

Mas 相关 G 蛋白偶联受体 (Mrgprs) 是涉及多种人类疾病的受体家族。自 2001 年发现它们以来，在确定它们与人类疾病的关系方面取得了很大进展。对所有疾病学科的 Mrgprs 治疗工作至关重要的是对 Mrgprs 信号转导途径和多态性的透彻了解，因为这些提供了对新候选药物、药物反应中现有差异以及疾病易感性差异的见解。在这篇综述中，我们讨论了有关 Mrgprs 信号通路和多态性的当前知识状态。