We estimated HLA allele and haplotype frequencies of the Saudi Arabian population from a sample of 45,457 registered stem cell donors. The most frequent HLA alleles were A*02:01g (18.5%), C*06:02g (16.1%), B*51:01g (14.1%), DRB1*07:01g (16.2%), DQB1*02:01g (30.5%), and DPB1*04:01g (33.6%). The most frequent 5-locus haplotypes were A*02:05g~C*06:02g~B*50:01g~DRB1*07:01g~DQB1*02:01g (1.73%), A*02:01g~C*06:02g~B*50:01g~DRB1*07:01g~DQB1*02:01g (1.66%), and A*26:01g~C*07:02g~B*08:01g~DRB1*03:01g~DQB1*02:01g (1.38%). Furthermore, we used the calculated haplotype frequencies to estimate stem cell donor matching probabilities for Saudi Arabian donor and patient populations under various matching requirements. These results are relevant for strategic donor registry planning in the Kingdom of Saudi Arabia.

我们从 45,457 名注册干细胞捐献者的样本中估计了沙特阿拉伯人群的 HLA 等位基因和单倍型频率。最常见的 HLA 等位基因是 A*02:01g (18.5%)、C*06:02g (16.1%)、B*51:01g (14.1%)、DRB1*07:01g (16.2%)、DQB1*02： 01g (30.5%) 和 DPB1*04:01g (33.6%)。最常见的 5 位点单倍型是 A*02:05g~C*06:02g~B*50:01g~DRB1*07:01g~DQB1*02:01g (1.73%), A*02:01g~C* 06:02g~B*50:01g~DRB1*07:01g~DQB1*02:01g (1.66%)，A*26:01g~C*07:02g~B*08:01g~DRB1*03:01g ~DQB1*02:01g (1.38%)。此外，我们使用计算的单倍型频率来估计沙特阿拉伯供体和患者群体在各种匹配要求下的干细胞供体匹配概率。这些结果与沙特阿拉伯王国的战略捐助者登记处规划相关。