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Alginate-chitosan Hydrogel Patch with Beta-glucan Nanoemulsion for Antibacterial Applications
Biotechnology and Bioprocess Engineering ( IF 3.2 ) Pub Date : 2020-12-31 , DOI: 10.1007/s12257-020-0177-4
Yonghyun Choi , Jaehee Jang , Hyung-Jun Koo , Masayoshi Tanaka , Keun-Heon Lee , Jonghoon Choi

Natural polymer materials have high biocompatibility and are not toxic because they can decompose into metabolites in the body; thus, they are widely used as medical polymer materials as well as porous support materials. As a biopolymer, alginate has a negative charge; in contrast, chitosan has a positive charge. Therefore, when the two substances are mixed, they form a relatively stable structure by ionic bonding. Beta-glucan is known to contribute to material stability and have high skin penetration, skin moisturizing and soothing effects, and burn and wound healing effects. In this study, antimicrobial activity was assessed by preparing alginate-chitosan hydrogel patches containing beta-glucan nanoemulsions. This could contribute to the development of wound dressings with antibacterial properties.



中文翻译:

含β-葡聚糖纳米乳的藻酸盐-壳聚糖水凝胶贴剂用于抗菌应用

天然高分子材料具有高生物相容性,并且无毒,因为它们可以在体内分解为代谢产物。因此,它们被广泛用作医用聚合物材料以及多孔载体材料。海藻酸盐作为生物聚合物带负电荷;相反,壳聚糖带正电荷。因此,当将两种物质混合时,它们通过离子键形成相对稳定的结构。众所周知,β-葡聚糖有助于提高材料的稳定性,并具有较高的皮肤渗透性,皮肤保湿和舒缓作用以及烧伤和伤口愈合作用。在这项研究中,通过制备含有β-葡聚糖纳米乳的藻酸盐-壳聚糖水凝胶贴剂来评估抗菌活性。这可能有助于开发具有抗菌特性的伤口敷料。

更新日期:2020-12-31
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