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Human Stem Cell-Derived Retinal Pigment Epithelial Cells as a Model for Drug Screening and Pre-Clinical Assays Compared to ARPE-19 Cell Line.
International Journal of Stem Cells ( IF 2.3 ) Pub Date : 2020-12-31 , DOI: 10.15283/ijsc20094
Carolina Reis Oliveira 1 , Mayara Rodrigues Brandão de Paiva 2 , Marcela Coelho Silva Ribeiro 2 , Gracielle Ferreira Andrade 3 , Juliana Lott Carvalho 4 , Dawidson Assis Gomes 1 , Márcio Nehemy 5 , Sílvia Ligório Fialho 6 , Armando Silva-Cunha 2 , Alfredo Miranda de Góes 1
Affiliation  

Eye diseases have a high socioeconomic impact on society and may be one of the fields in which most stem cell-related scientific accomplishments have been achieved recently. In this context, human Pluripotent Stem Cell (hPSC) technology arises as an important tool to produce and study human Embryonic Stem cell derived-Retinal Pigmented Epithelial Cells (hES-RPE) for several applications, such as cell therapy, disease modeling, and drug screening. The use of this technology in pre-clinical phases attends to the overall population desire for animal-free product development. Here, we aimed to compare hES-RPE cells with ARPE-19, one of the most commonly used retinal pigmented epithelial immortalized cell lines.

中文翻译:

与 ARPE-19 细胞系相比,人类干细胞衍生的视网膜色素上皮细胞作为药物筛选和临床前检测的模型。

眼部疾病对社会具有很高的社会经济影响,可能是最近取得大多数干细胞相关科学成就的领域之一。在此背景下,人类多能干细胞 (hPSC) 技术成为生产和研究人类胚胎干细胞衍生的视网膜色素上皮细胞 (hES-RPE) 的重要工具,用于细胞治疗、疾病建模和药物等多种应用筛选。在临床前阶段使用该技术可以满足总体人群对无动物产品开发的需求。在这里,我们旨在将 hES-RPE 细胞与 ARPE-19 进行比较,ARPE-19 是最常用的视网膜色素上皮永生化细胞系之一。
更新日期:2021-01-01
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