Stenosis can disrupt the normal pattern of blood flow and make the artery more susceptible to buckling which may cause arterial tortuosity. Although the stability simulations of the atherosclerotic arteries were conducted based on solid modeling and static internal pressure, the mechanical stability of stenotic artery under pulsatile blood flow remains unclear while pulsatile nature of blood flow makes the artery more critical for stresses and stability. In this study, the effect of stenosis on arterial stability under pulsatile blood flow was investigated. Fluid–structure interaction (FSI) simulations of artery stenosis under pulsatile flow were conducted. 3D idealized geometries of carotid artery stenosis with symmetric and asymmetric plaques along with different percentages of stenosis were created. It was observed that the stenosis percentage, symmetry/asymmetry of the plaque, and the stretch ratio can dramatically affect the buckling pressure. Buckling makes the plaques (especially in asymmetric ones) more likely to rupture due to increasing the stresses on it. The dominant stresses on plaques are the circumferential, axial and radial ones, respectively. Also, the highest shear stresses on the plaques were detected in [Formula: see text] and [Formula: see text] planes for the symmetric and asymmetric stenotic arteries, respectively. In addition, the maximum circumferential stress on the plaques was observed in the outer point of the buckled configuration for symmetric and asymmetric stenosis as well as at the ends of the asymmetric plaque. Furthermore, the artery buckling causes a large vortex flow at the downstream of the plaque. As a result, the conditions for the penetration of lipid particles and the formation of new plaques are provided.

中文翻译：

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使用流体-结构相互作用方法计算脉动血流下狭窄颈动脉稳定性的计算研究

狭窄会破坏正常的血流模式，使动脉更容易弯曲，从而导致动脉迂曲。尽管动脉粥样硬化动脉的稳定性模拟是基于实体模型和静态内压进行的，但脉动血流下狭窄动脉的机械稳定性仍不清楚，而血流的脉动性质使动脉对应力和稳定性更加关键。在这项研究中，研究了脉动血流下狭窄对动脉稳定性的影响。进行了脉动流下动脉狭窄的流固耦合 (FSI) 模拟。创建了具有对称和不对称斑块以及不同狭窄百分比的颈动脉狭窄的 3D 理想化几何形状。观察到狭窄百分比，斑块的对称性/不对称性，拉伸比会显着影响屈曲压力。屈曲使斑块（尤其是不对称的斑块）更容易由于其上的应力而破裂。板上的主要应力分别是周向应力、轴向应力和径向应力。此外，分别在对称和不对称狭窄动脉的 [公式：见文本] 和 [公式：见文本] 平面中检测到斑块上的最高剪切应力。此外，在对称和不对称狭窄的弯曲结构的外点以及不对称斑块的末端观察到斑块上的最大周向应力。此外，动脉屈曲在斑块下游引起大的涡流。因此，