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Cenote-Taker 2 democratizes virus discovery and sequence annotation
Virus Evolution ( IF 5.3 ) Pub Date : 2020-12-30 , DOI: 10.1093/ve/veaa100
Michael J Tisza 1 , Anna K Belford 1 , Guillermo Domínguez-Huerta 2 , Benjamin Bolduc 2 , Christopher B Buck 1
Affiliation  

Abstract
Viruses, despite their great abundance and significance in biological systems, remain largely mysterious. Indeed, the vast majority of the perhaps hundreds of millions of viral species on the planet remain undiscovered. Additionally, many viruses deposited in central databases like GenBank and RefSeq are littered with genes annotated as ‘hypothetical protein’ or the equivalent. Cenote-Taker 2, a virus discovery and annotation tool available on command line and with a graphical user interface with free high-performance computation access, utilizes highly sensitive models of hallmark virus genes to discover familiar or divergent viral sequences from user-input contigs. Additionally, Cenote-Taker 2 uses a flexible set of modules to automatically annotate the sequence features of contigs, providing more gene information than comparable tools. The outputs include readable and interactive genome maps, virome summary tables, and files that can be directly submitted to GenBank. We expect Cenote-Taker 2 to facilitate virus discovery, annotation, and expansion of the known virome.


中文翻译:

Cenote-Taker 2使病毒发现和序列注释民主化

摘要
尽管病毒在生物系统中具有巨大的丰富性和重要性,但它们在很大程度上仍然神秘。确实,地球上可能有数亿个病毒物种中的绝大多数仍未被发现。此外,许多存放在中央数据库中的病毒(如GenBank和RefSeq)都带有注有“假设蛋白”或等同物的基因。Cenote-Taker 2是一种病毒发现和注释工具,可在命令行上使用,并具有可免费使用高性能计算访问的图形用户界面,它利用标志性病毒基因的高度敏感模型从用户输入的重叠群中发现熟悉或不同的病毒序列。另外,Cenote-Taker 2使用了一组灵活的模块来自动注释重叠群的序列特征,比同类工具提供更多的基因信息。输出包括可读和交互式的基因组图谱,病毒摘要表以及可以直接提交给GenBank的文件。我们希望Cenote-Taker 2能够促进病毒的发现,注释和已知病毒体的扩展。
更新日期:2021-01-20
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