Immunological memory is classically attributed to adaptive immune responses, but recent studies have shown that challenged innate immune cells can display long-term functional changes that increase nonspecific responsiveness to subsequent infections. This phenomenon, coined trained immunity or innate immune memory, is based on the epigenetic reprogramming and the rewiring of intracellular metabolic pathways. Here, we review the different metabolic pathways that are modulated in trained immunity. Glycolysis, oxidative phosphorylation, the tricarboxylic acid cycle, amino acid, and lipid metabolism are interplaying pathways that are crucial for the establishment of innate immune memory. Unraveling this metabolic wiring allows for a better understanding of innate immune contribution to health and disease. These insights may open avenues for the development of future therapies that aim to harness or dampen the power of the innate immune response.
J Innate Immun

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细胞代谢在先天免疫记忆中的作用

免疫记忆通常归因于适应性免疫反应，但最近的研究表明，受到挑战的先天免疫细胞可以表现出长期的功能变化，从而增加对后续感染的非特异性反应。这种现象，创造了训练有素的免疫或先天免疫记忆，基于表观遗传重编程和细胞内代谢途径的重新布线。在这里，我们回顾了受过训练的免疫调节的不同代谢途径。糖酵解、氧化磷酸化、三羧酸循环、氨基酸和脂质代谢是对建立先天免疫记忆至关重要的相互作用途径。解开这种代谢线路可以更好地了解先天免疫对健康和疾病的贡献。这些见解可能为开发旨在利用或抑制先天免疫反应力量的未来疗法开辟道路。
J先天免疫