ABSTRACT

The present research was aimed at synthesising and characterising curcumin-loaded zinc oxide nanoparticle-decorated mesoporous silica as a tissue adhesive (Liquid Stitches). The mesoporous silica nanoparticles facilitate adhesion to tissues through the nanobridging effect. The mesoporous silica was synthesised using a sol–gel methodology, and the drug was incorporated using the wetness impregnation method. The platform that was prepared was characterised using infrared spectroscopy, TEM, DSC, XRD, particle size analysis, BET analysis, a tissue model adhesion test, an antimicrobial assay and a wound model in Sprague Dawley rats. The average particle size was found to be 72.4 nm, while the surface area was found to be 654 m²/g. The tissue model adhesion graphs showed significantly different values for the peak load, work done and deformation at peak load, which reflects a difference between the glue strengths of the mesoporous silica nanoparticles and the Cur-ZnO-MSN and the carrier medium (water). The animal study provided a proof of concept by glueing wounds in less than 1 minute and healing the wound within 5 days.

摘要

本研究旨在合成和表征负载姜黄素的氧化锌纳米颗粒装饰的介孔二氧化硅作为组织粘合剂（液体缝合）。介孔二氧化硅纳米粒子通过纳米桥接效应促进与组织的粘附。介孔二氧化硅采用溶胶-凝胶法合成，药物采用湿法浸渍法掺入。使用红外光谱、TEM、DSC、XRD、粒度分析、BET 分析、组织模型粘附试验、抗菌试验和 Sprague Dawley 大鼠的伤口模型对所制备的平台进行了表征。平均粒径为 72.4 nm，而表面积为 654 m ²/G。组织模型粘附图显示峰值负载、完成的功和峰值负载下的变形值显着不同，这反映了介孔二氧化硅纳米粒子与 Cur-ZnO-MSN 和载体介质（水）的粘合强度之间的差异。动物研究通过在不到 1 分钟的时间内粘合伤口并在 5 天内治愈伤口提供了概念证明。