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Human Brain Surrogates Research: The Onrushing Ethical Dilemma
The American Journal of Bioethics ( IF 13.4 ) Pub Date : 2020-12-29 , DOI: 10.1080/15265161.2020.1845853
Henry T. Greely 1
Affiliation  

Abstract

Human brain research is moving into a dilemma. The best way to understand how the human brain works is to study living human brains in living human beings, but ethical and legal standards make it difficult to do powerful research with actual human beings. So neuroscientists have developed four types of surrogates for living human brains in human bodies: genetically edited non-human animals, human/non-human brain chimeras, human neural organoids, and living ex vivo human brain tissues. These new and rapidly improving models offer the hope of understanding human brain function better. If we make our models “too good,” they may themselves deserve some of the kinds of ethical and legal respect that have limited brain research in human beings. This article is an initial effort to outline that dilemma.



中文翻译:

人脑代孕研究:激进的伦理困境

摘要

人脑研究正陷入两难境地。理解人脑工作原理的最好方法是在活人中研究活人的大脑,但是道德和法律标准使得很难对实际的人进行有力的研究。因此,神经科学家已经开发出四种类型的替代物,以替代人体内的活人脑:转基因非人动物,人/非人脑嵌合体,人神经器官和活体外人脑组织。这些新的,快速改进的模型提供了更好地了解人脑功能的希望。如果我们将模型“太好”,它们本身可能值得某些道德和法律方面的尊重,而这些道德和法律方面的尊重对人类的大脑研究是有限的。本文是概述这一难题的初步工作。

更新日期:2020-12-30
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