Abstract

A new cyclo-heptadepsipeptide xanthostatin B (1), together with isobutyryl hexapeptide (2), xanthostatin (3), TXS-1 (4) and TXS-2 (5), were isolated from the marine sponge derived Streptomyces sp. SCSIO 40064. The structures were elucidated by comprehensive spectroscopic data analyses and comparison with the literatures. The D-Val unit in 1 was assigned by Marfey’s method. The absolute configuration of 4 was determined by X-ray crystallographic analysis. Compounds 1‒5 were evaluated for the inhibitory activities against four pharmaceutical targets and six antibacterial indicator strains. Compound 5 displayed α-glucosidase inhibitory activity with IC₅₀ value of 18.67 ± 1.27 µM.

摘要

从海绵衍生的链霉菌中分离出一种新的环七肽黄素 B ( 1 )，以及异丁酰六肽 ( 2 )、黄素 ( 3 )、TXS-1 ( 4 ) 和 TXS-2 ( 5 ) 。SCIO 40064。通过全面的光谱数据分析和与文献的比较，阐明了结构。1中的 D-Val 单位由 Marfey 方法指定。4的绝对构型由X射线晶体学分析确定。化合物1 - 5对四种药物靶点和六种抗菌指示菌株的抑制活性进行了评估。化合物5显示出α-葡萄糖苷酶抑制活性，IC ₅₀值为18.67 ± 1.27 µM。