The use of calcineurin inhibitors such as cyclosporine A (CsA) for immunosuppression after solid organ transplantation is commonly limited by renal side effects. CsA-induced deterioration of glomerular filtration rate and sodium retention may be related to juxtaglomerular dysregulation as a result of suppressed cyclooxygenase 2 (COX-2) and stimulated renin biosynthesis. We tested whether CsA-induced COX-2 suppression is caused by hyperactive renin-angiotensin system (RAS) and whether RAS inhibition may alleviate the related side effects.

中文翻译：

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血管紧张素II受体阻滞剂通过恢复肾皮质中的环氧合酶2表达来减轻钙调神经磷酸酶抑制剂的肾毒性

肾器官副作用通常限制了钙调神经磷酸酶抑制剂（例如环孢素A（CsA））在实体器官移植后用于免疫抑制的用途。CsA诱导的肾小球滤过率和钠retention留的恶化可能与环氧合酶2（COX-2）抑制和肾素生物合成受刺激而引起的肾小球调节异常有关。我们测试了CsA诱导的COX-2抑制是否由过度活跃的肾素-血管紧张素系统（RAS）引起，以及RAS抑制是否可以减轻相关的副作用。