Biopesticides are gaining interests as an alternative to chemical-based pesticides for arthropod pest management. Among the widely-used biopesticides is the entomopathogenic fungi Beauveria bassiana due to its efficacy and broad range of arthropod hosts. Although the general mechanisms of infection by B. bassiana are known, the underlying complexity of molecular mechanisms at each infection stage is largely not well-understood. Characterising the mechanisms of pathogenicity allows for a more effective pest control by synergising between multiple pesticides or biopesticides without overlapping modes of action and by characterising novel toxic molecules that can expand the biopesticide arsenal. Systems biology refers to a large scale, high-throughput analysis of biological molecules at the systemic level. It incorporates the ‘omics’ methods, allowing identification of genes (genomics), along with their RNA (transcriptomics), proteins (proteomics) and metabolites (metabolomics) expression levels. The high-throughput research approach accelerates the process of characterising pathogenicity. The use of omics is a powerful tool to drive the discovery of the complex process of B. bassiana infections. This review categorises infection processes into distinct steps, and presents the overview of the genes, proteins and metabolite expressions relevant for the B. bassiana pathogenicity.

作为节肢动物害虫管理的一种替代化学农药的方法，生物农药正在引起人们的兴趣。由于其功效和节肢动物宿主的广泛性，在广泛使用的生物农药中有虫病真菌球孢白僵菌。尽管球孢杆菌感染的一般机制众所周知，每个感染阶段分子机制的潜在复杂性在很大程度上尚不为人所理解。通过在多种农药或生物农药之间协同作用而没有重叠的作用方式，并通过表征可以扩展生物农药库的新型有毒分子，对致病性机理进行表征可以实现更有效的害虫控制。系统生物学是指在系统水平上对生物分子进行的大规模，高通量分析。它结合了“组学”方法，可以鉴定基因（基因组学）及其RNA（转录组学），蛋白质（蛋白质组学）和代谢物（代谢组学）的表达水平。高通量研究方法加快了表征致病性的过程。B. bassiana感染。这篇综述将感染过程分为不同的步骤，并概述了与球孢杆菌致病性相关的基因，蛋白质和代谢物表达。