The genus Salvia is regarded as an important medicinal plant and also as spice worldwide. Current report might be counted as one of the first investigations to reveal the enzyme inhibitory and antiglycation activities, together with phenolic and antioxidant profiles of 80% methanolic extract prepared from the aerial parts of S.virgata (SVM). Furthermore, the bioavailability parameters of major phenolic compounds in SVM were evaluated. An in vitro human digestion simulation model composed of both gastric and intestinal phases was used for this purpose. Total phenolic, phenolic acid and flavonoid components of each of these phases were calculated in order to assess the phenolic profile of the samples. In addition, quantitative analysis of major bioactive compounds (rutin and rosmarinic acid), before and after the simulation, was practiced by employing High Performance Thin Layer Chromatography (HPTLC) system. Moreover, the potential of non-digested (ND) and bioavailable (IN) phases on the inhibition of diabetes-related enzymes (α-amylase and α-glucosidase) was determined. Also, the inhibitory effect of the samples on the advanced glycation end products (AGEs), formed due to hyperglycemia, was detected. In addition, cholinesterase enzyme inhibition activity of both ND and IN samples was determined. Since, the role of oxidative stress on diabetes and neurodegenerative diseases is well-known, the antioxidant potential of the samples was also estimated by different methods: DPPH and DMPD tests for free radical scavenging activity, FRAP and CUPRAC tests for metal reducing activity and total antioxidant capacity test, as well. The results showed that total phenolic contents, antioxidant potential and diabetes-related and cholinesterase enzymes inhibition of the bioavailable phase were lower than non-digested sample. Besides, in vitro human digestion simulation system had a declining influence on the concentrations of the major bioactive metabolites (rutin and rosmarinic acid).

属丹参被视为一个重要的药用植物，也可以作为香料全世界。本报告可能被认为是揭示酶抑制和抗糖基化活性的首批研究之一，而且还发现了由S.virgata（SVM）地上部分制得的80％甲醇提取物的酚和抗氧化特性。此外，评估了支持向量机中主要酚类化合物的生物利用度参数。一种在体外为此，使用了由胃和肠相组成的人体消化模拟模型。计算这些相中每个相的总酚，酚酸和类黄酮成分，以评估样品的酚谱。此外，通过使用高性能薄层色谱（HPTLC）系统对模拟前后的主要生物活性化合物（芦丁和迷迭香酸）进行定量分析。此外，确定了未消化（ND）和生物利用（IN）阶段抑制糖尿病相关酶（α-淀粉酶和α-葡萄糖苷酶）的潜力。此外，还检测到样品对由于高血糖形成的晚期糖基化终产物（AGEs）的抑制作用。此外，测定了ND和IN样品的胆碱酯酶抑制活性。由于氧化应激在糖尿病和神经退行性疾病中的作用是众所周知的，因此还可以通过不同的方法估算样品的抗氧化潜力：DPPH和DMPD检测自由基清除活性，FRAP和CUPRAC检测金属还原活性以及总和抗氧化剂容量测试也是如此。结果表明，总酚含量，抗氧化能力以及与糖尿病相关的胆碱酯酶和生物利用相的抑制作用均低于未消化样品。除了，FRAP和CUPRAC测试还包括金属还原活性测试和总抗氧化能力测试。结果表明，总酚含量，抗氧化能力以及与糖尿病相关的胆碱酯酶和生物利用相的抑制作用均低于未消化样品。除了，FRAP和CUPRAC测试还包括金属还原活性测试和总抗氧化能力测试。结果表明，总酚含量，抗氧化能力以及与糖尿病相关的胆碱酯酶和生物利用相的抑制作用均低于未消化样品。除了，体外人体消化模拟系统对主要生物活性代谢物（芦丁和迷迭香酸）的浓度具有下降的影响。