The assessment of renal function in birds is difficult because sensitive biomarkers are lacking. Previous studies have demonstrated the feasibility of measuring the exogenous creatinine clearance in pigeons, indicating the potential use of this technique for the assessment of renal function in birds. The aim of the study was to index the exogenous creatinine elimination rate by body surface area, enabling comparison between different species. Exploratory data on common buzzards (Buteo buteo), Eurasian eagle-owls (Bubo bubo), domestic goose (Anser anser domesticus) and racing pigeons (Columba livia) were collected and indexed by body surface area. A sterile creatinine solution was administered at a dose D_M = 50 mg kg⁻¹ i.m. into the deep pectoral muscle of 52 clinically healthy birds of the four species with different body masses. The time course of the plasma creatinine concentration was measured and analyzed by a parametric pharmacokinetic Bateman model, followed by indexing the exogenous creatinine clearance (ECC) by body surface area. The exploratory ECC values for birds with a mean body mass ranging from 0.42 kg (pigeon) to 8.2 kg (goose) were between 0.4261 mL min⁻¹ dm⁻² (CI 0.3882–0.4672) and 0.8717 mL min⁻¹ dm⁻² (CI 0.8091–0.9362). ECC indexed by body surface area turned out to be independent from body mass. Resulting exploratory data covering species with different body masses are comparable with published data from very complex studies of avian renal function.

由于缺乏敏感的生物标志物，很难评估禽类的肾功能。先前的研究表明，测量鸽子中外源性肌酐清除率的可行性，表明该技术可能用于评估鸟类的肾功能。这项研究的目的是通过体表面积来索引外源性肌酐消除率，从而能够在不同物种之间进行比较。收集有关普通秃鹰（Buteo buteo），欧亚鹰（Bubo bubo），家鹅（Anser anser domesticus）和赛鸽（Columba livia）的探索性数据，并按体表索引。无菌肌酐溶液的剂量为D _M = 50 mg kg ^-1 im进入4种不同体重的52种临床健康鸟类的胸深肌。通过参数药代动力学Bateman模型测量并分析血浆肌酐浓度的时程，然后通过身体表面积索引外源性肌酐清除率（ECC）。平均体重在0.42 kg（鸽子）至8.2 kg（鹅）之间的鸟类的探索性ECC值在0.4261 mL min ^-1  dm ^-2（CI 0.3882-0.4672）和0.8717 mL min ^-1  dm ^-2之间（CI 0.8091-0.9362）。通过身体表面积索引的ECC证明与体重无关。最终的探索性数据涵盖了具有不同体重的物种，这与禽类肾功能的非常复杂的研究发表的数据相当。