Numerous biopolymer-based functional composites have been developed for medical applications. Poly(glutamic acid) (PGA) is an amino acid biopolymer that has recently attracted attention due to its biocompatibility, non-immunogenicity, and biodegradability. PGA and its composites have been studied to improve their function as medical materials. This review briefly introduces chemically and microbiologically synthesized PGA. In addition, this article provides general and advanced preparation methods for various PGA-based composites, including hydrogels, nanofibers, monoliths, and nanoparticles. Furthermore, it covers recent advances in PGA-based functional composites for medical applications, such as active antimicrobial materials as well as the use of PGA composites for vaccine adjuvants, cancer therapy, medical devices, and tissue regeneration. Anticancer agent delivery and cancer immunotherapy are included in the PGA-based cancer therapy system section. Barrier membranes and stent applications are summarized within the medical devices section. Furthermore, various tissue regeneration topics are introduced, including applications in wound healing, as well as the tissue-specific regeneration of bone, cartilage, intervertebral discs, corneas, kidneys, and neurons. In summary, this is an overview of the various challenges of using PGA and the scope of emerging research.

已经开发出许多基于生物聚合物的功能复合材料用于医学应用。聚谷氨酸（PGA）是一种氨基酸生物聚合物，由于其生物相容性，非免疫原性和生物降解性，最近引起了人们的关注。已经对PGA及其复合材料进行了研究，以改善其作为医用材料的功能。本文简要介绍了化学和微生物合成的PGA。此外，本文提供了各种基于PGA的复合材料的常规和高级制备方法，包括水凝胶，纳米纤维，整料和纳米颗粒。此外，它涵盖了用于医疗应用的基于PGA的功能复合材料（例如活性抗菌材料）的最新进展，以及PGA复合材料在疫苗佐剂，癌症治疗，医疗设备和组织再生中的应用。基于PGA的癌症治疗系统部分中包括抗癌剂递送和癌症免疫治疗。屏障膜和支架的应用总结在医疗设备部分。此外，介绍了各种组织再生主题，包括在伤口愈合中的应用以及骨骼，软骨，椎间盘，角膜，肾脏和神经元的组织特异性再生。总而言之，本文概述了使用PGA的各种挑战以及新兴研究的范围。以及骨骼，软骨，椎间盘，角膜，肾脏和神经元的组织特异性再生。总而言之，本文概述了使用PGA的各种挑战以及新兴研究的范围。以及骨骼，软骨，椎间盘，角膜，肾脏和神经元的组织特异性再生。总而言之，本文概述了使用PGA的各种挑战以及新兴研究的范围。