A novel fluorescence sensor was designed for the determination of doxorubicin hydrochloride (DOX) based on polyethyleneimine-functionalized carbon dots (PEI-CDs). The PEI-CDs were simply prepared using citric acid as a carbon source and PEI as a modifier based on the “synthesis-modification integration” method. The prepared PEI-CDs exhibited excellent optical properties, and the fluorescence emission was efficiency quenched in the presence of DOX based on inner filter effect (IFE). There was a linear relationship between quenching efficiency and DOX concentration in the range of 0.1–150 μM under the best detection conditions, and the detection limit as low as 75.2 nM. In addition, the new IFE-based sensing platform was successfully used to detect DOX in real samples with satisfactory results obtained.

基于聚乙烯亚胺官能化的碳点（PEI-CD），设计了一种新型的荧光传感器，用于测定盐酸阿霉素（DOX）。仅使用柠檬酸作为碳源和PEI作为改性剂，即可根据“合成-改性整合”方法制备PEI-CD。所制备的PEI-CD表现出优异的光学性能，并且基于内部滤光效应（IFE），在存在DOX的情况下有效地猝灭了荧光发射。在最佳检测条件下，猝灭效率与DOX浓度在0.1–150μM之间存在线性关系，检测限低至75.2 nM。此外，新的基于IFE的传感平台已成功用于检测真实样品中的DOX，并获得了令人满意的结果。