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Aptamer-functionalized metal-organic frameworks (MOFs) for biosensing
Biosensors and Bioelectronics ( IF 12.6 ) Pub Date : 2020-12-30 , DOI: 10.1016/j.bios.2020.112947
Mengzhen Lv 1 , Wan Zhou 2 , Hamed Tavakoli 2 , Cynthia Bautista 2 , Jianfei Xia 1 , Zonghua Wang 3 , XiuJun Li 4
Affiliation  

As a class of crystalline porous materials, metal-organic frameworks (MOFs) have attracted increasing attention. Due to the nanoscale framework structure, adjustable pore size, large specific surface area, and good chemical stability, MOFs have been applied widely in many fields such as biosensors, biomedicine, electrocatalysis, energy storage and conversions. Especially when they are combined with aptamer functionalization, MOFs can be utilized to construct high-performance biosensors for numerous applications ranging from medical diagnostics and food safety inspection, to environmental surveillance. Herein, this article reviews recent innovations of aptamer-functionalized MOFs-based biosensors and their bio-applications. We first briefly introduce different functionalization methods of MOFs with aptamers, which provide a foundation for the construction of MOFs-based aptasensors. Then, we comprehensively summarize different types of MOFs-based aptasensors and their applications, in which MOFs serve as either signal probes or signal probe carriers for optical, electrochemical, and photoelectrochemical detection, with an emphasis on the former. Given recent substantial research interests in stimuli-responsive materials and the microfluidic lab-on-a-chip technology, we also present the stimuli-responsive aptamer-functionalized MOFs for sensing, followed by a brief overview on the integration of MOFs on microfluidic devices. Current limitations and prospective trends of MOFs-based biosensors are discussed at the end.



中文翻译:

用于生物传感的适体功能化金属有机框架(MOF)

作为一类结晶多孔材料,金属有机框架(MOF)引起了越来越多的关注。MOFs由于具有纳米级骨架结构、孔径可调、比表面积大、化学稳定性好等优点,在生物传感器、生物医学、电催化、能量储存与转换等领域得到广泛应用。特别是当它们与适体功能化相结合时,MOF 可用于构建高性能生物传感器,适用于从医疗诊断、食品安全检查到环境监测等众多应用。本文综述了基于适配体功能化 MOF 的生物传感器的最新创新及其生物应用。我们首先简要介绍了MOFs与适配体的不同功能化方法,为基于MOFs的适配体传感器的构建提供了基础。然后,我们全面总结了不同类型的基于MOF的适体传感器及其应用,其中MOF作为信号探针或信号探针载体用于光学、电化学和光电化学检测,重点是前者。鉴于最近对刺激响应材料和微流控芯片实验室技术的大量研究兴趣,我们还介绍了用于传感的刺激响应适体功能化 MOF,随后简要概述了 MOF 在微流控设备上的集成。最后讨论了基于 MOF 的生物传感器的当前局限性和未来趋势。

更新日期:2021-01-04
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