Abstract

The method of obtaining hydrogels from sodium alginate interpolymer complexes with the copolymer of methyl vinyl ether and maleic anhydride is developed. It is shown that the interpolymer network is formed via hydrogen bonding between the hydroxyl groups of alginate and the carboxyl groups of the copolymer. The structure of the network, namely, the type of bonds and their density, is primarily controlled by the treatment temperature of the polymer mixture. Using lidocaine as a model drug, it is demonstrated that these complexes can be used as a platform for рН-tunable drug delivery systems.

中文翻译：

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海藻酸钠共聚复合物作为可调节pH值的药物载体的平台

摘要

开发了从藻酸钠互聚物与甲基乙烯基醚和马来酸酐的共聚物中获得水凝胶的方法。结果表明，互聚物网络是通过藻酸盐的羟基与共聚物的羧基之间的氢键形成的。网络的结构，即键的类型及其密度，主要受聚合物混合物的处理温度控制。使用利多卡因作为模型药物，证明了这些复合物可以用作р可调药物递送系统的平台。