Abstract

Epilepsy is characterized as recurrent seizures, and it is one of the most prevalent disorders of the human nervous system. A large and diverse profile of different syndromes and conditions can cause perturbations in neural networks that are associated with epilepsy. Advances in neuroimaging and electrophysiological monitoring have enhanced our ability to localize the neuropathological lesions that alter the neural networks giving rise to epilepsy, whereas advances in surgical management have resulted in excellent seizure control in many patients following resections. Histopathologic study using a variety of special stains, molecular analysis, and functional studies of these resected tissues has facilitated the neuropathological characterization of these lesions. Here, we review the neuropathology of common structural lesions that cause epilepsy and are amenable to neurosurgical resection, such as hippocampal sclerosis, focal cortical dysplasia, and its associated principal lesions, including long-term epilepsy-associated tumors, as well as other malformations of cortical development and Rasmussen encephalitis.

中文翻译：

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评论：神经外科医师代表大会系统性审查和针对癌痛患者的神经消融手术的循证指南

摘要

癫痫病的特征是反复发作，是人类神经系统最普遍的疾病之一。不同综合症和病状的广泛多样的分布图可能会导致与癫痫相关的神经网络扰动。神经影像学和电生理监测的进步增强了我们定位改变神经网络从而引起癫痫的神经病理病变的能力，而外科治疗的进步已使许多患者在切除术后实现了出色的癫痫发作控制。使用各种特殊染色的组织病理学研究，分子分析和这些切除组织的功能研究促进了这些病变的神经病理学表征。这里，