There are few data on the effects on TAG, glucose and uric acid of chronic consumption of a moderate dose of fructose in solid foods. Twenty-eight participants with prediabetes and/or obesity and overweight commenced the study (BMI 32·3 kg/m2, age 44·7 years, fasting glucose 5·3 (sd 0·89) mmol/l and 2-h glucose 6·6 (sd 1·8) mmol/l). Twenty-four men and women who completed the study consumed, in random order, two acute test meals of muffins sweetened with either fructose or sucrose. This was followed by 4-week chronic consumption of 42 g/d of either fructose or sucrose in low-fat muffins after which the two meal tests were repeated. The sugar type in the chronic feeding period was also randomised. Fasting TAG increased after chronic consumption of fructose by 0·31 (sd 0·37) mmol/l compared with sucrose in those participants with impaired fasting glucose (IFG)/impaired glucose tolerance (IGT) (P = 0·004). Total cholesterol (0·33 mmol/l), LDL-cholesterol (0·24 mmol/l) and HDL-cholesterol (0·08 mmol/l) increased significantly over the 1- month feeding period with no differences between muffin types. Fasting glucose was not different after 1 month of muffin consumption. Uric acid response was not different between the two sugar types either baseline or 1 month, and there were no differences between baseline and 1 month. The increase in fasting TAG in participants with IFG/IGT suggests the need for caution in people at increased risk of type 2 diabetes.

中文翻译：

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固体食物中适量果糖对 1 个月中等糖喂养期前后 TAG、葡萄糖和尿酸的影响

关于在固体食物中长期食用中等剂量的果糖对 TAG、葡萄糖和尿酸的影响的数据很少。28 名患有前驱糖尿病和/或肥胖和超重的参与者开始了研究（BMI 32·3 kg/m2, 年龄 44·7 岁, 空腹血糖 5·3 (sd0·89) mmol/l 和 2-h 葡萄糖 6·6 (sd1·8) 毫摩尔/升)。完成研究的 24 名男性和女性以随机顺序食用了两顿用果糖或蔗糖加糖的松饼的急性试验餐。随后在低脂松饼中连续 4 周长期摄入 42 克果糖或蔗糖，然后重复两次膳食测试。慢性喂养期的糖类型也是随机的。长期食用果糖后空腹 TAG 增加 0·31 (sd空腹血糖受损 (IFG)/糖耐量受损 (IGT) 参与者与蔗糖相比 0·37) mmol/l (磷= 0·004)。总胆固醇 (0·33 mmol/l)、LDL-胆固醇 (0·24 mmol/l) 和 HDL-胆固醇 (0·08 mmol/l) 在 1 个月的喂养期间显着增加，松饼类型之间没有差异。食用松饼 1 个月后，空腹血糖没有变化。无论是基线还是 1 个月，两种糖类型的尿酸反应没有差异，基线和 1 个月之间没有差异。IFG/IGT 参与者的空腹 TAG 增加表明需要谨慎对待 2 型糖尿病风险增加的人。