Abstract

Purpose

Progressive loss of dopaminergic neurons in basal ganglia is blamed as the main source of gait disturbance in Parkinson's disease (PD). It is known that the normal step pattern does not disappear in PD, but there is a problem in activating the correct step response. The aim of this study was to investigate the effect of Rhythmic Auditory Stimulation (RAS), which is an external stimulus, on gait in individuals with PD.

Materials and methods

Twenty-six individuals, 13 in the PD group and 13 in the control group, participated in the study. All individuals were asked to walk under four different RAS conditions configured with beat frequency and melodic variations. Time–distance parameters and gait performance of the individuals were evaluated.

Results

RAS significantly increased the gait speed of the individuals with PD compared to the control group. RAS set to 10% increase in the cadence of the patient with melody (10 M+) was found to be more effective than the RAS set to normal cadence of the patient without melody (0 M-) (p < 0.05). While all RAS implementations increased the stride length of the individuals with PD (p < 0.05), there was no change in the control group. RAS did not affect the return time in both groups.

Conclusions

Our study has shown that RAS implementation improves gait in individuals with PD both in terms of time–distance parameters and performance, especially when set to 10% more than the patient's gait cadence. It was concluded that cadence-compatible melodic RAS can be safely included in PD rehabilitation programs.

中文翻译：

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节奏相容的旋律节奏听觉刺激实施对帕金森病患者步态的影响

摘要

目的

基底神经节中多巴胺能神经元的逐渐丧失被认为是帕金森病 (PD) 步态障碍的主要来源。众所周知，正常的阶跃模式在 PD 中不会消失，但在激活正确的阶跃响应方面存在问题。本研究的目的是研究节律性听觉刺激 (RAS)（一种外部刺激）对 PD 患者步态的影响。

材料和方法

26 个人，PD 组 13 人，对照组 13 人，参与了这项研究。所有个体都被要求在四种不同的 RAS 条件下行走，这些条件配置有节拍频率和旋律变化。评估个体的时间-距离参数和步态表现。

结果

与对照组相比，RAS 显着提高了 PD 患者的步态速度。发现将 RAS 设置为有旋律的患者的节奏增加 10% (10  M+) 比将 RAS 设置为没有旋律的患者的正常节奏 (0 M-) 更有效 ( p  < 0.05)。虽然所有 RAS 实施都增加了 PD 个体的步幅 ( p  < 0.05)，但对照组没有变化。RAS 不影响两组的返回时间。

结论

我们的研究表明，RAS 实施在时间-距离参数和性能方面改善了 PD 患者的步态，尤其是当设置为比患者步态节奏高 10% 时。得出的结论是，节奏兼容的旋律 RAS 可以安全地包含在 PD 康复计划中。