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Immunomodulatory effects of nanocurcumin on Th17 cell responses in mild and severe COVID‐19 patients
Journal of Cellular Physiology ( IF 5.6 ) Pub Date : 2020-12-28 , DOI: 10.1002/jcp.30233
Safa Tahmasebi 1 , Mohamed A. El‐Esawi 2 , Zaid Hameed Mahmoud 3 , Anton Timoshin 4 , Hamed Valizadeh 5 , Leila Roshangar 6 , Mojtaba Varshoch 7 , Aydin Vaez 7 , Saeed Aslani 8 , Jamshid G. Navashenaq 9 , Leili Aghebati‐Maleki 10 , Majid Ahmadi 6
Affiliation  

In novel coronavirus disease 2019 (COVID‐19), the increased frequency and overactivation of T helper (Th) 17 cells and subsequent production of large amounts of proinflammatory cytokines result in hyperinflammation and disease progression. The current study aimed to investigate the therapeutic effects of nanocurcumin on the frequency and responses of Th17 cells in mild and severe COVID‐19 patients. In this study, 40 severe COVID‐19 intensive care unit‐admitted patients and 40 patients in mild condition were included. The frequency of Th17 cells, the messenger RNA expression of Th17 cell‐related factors (RAR‐related orphan receptor γt, interleukin [IL]‐17, IL‐21, IL‐23, and granulocyte‐macrophage colony‐stimulating factor), and the serum levels of cytokines were measured in both nanocurcumin and placebo‐treated groups before and after treatment. A significant decrease in the number of Th17 cells, downregulation of Th17 cell‐related factors, and decreased levels of Th17 cell‐related cytokines were found in mild and severe COVID‐19 patients treated by nanocurcumin compared to the placebo group. Moreover, the abovementioned parameters were significantly decreased in the nanocurcumin‐treated group after treatment versus before treatment. Curcumin could reduce the frequency of Th17 cells and their related inflammatory factors in both mild and severe COVID‐19 patients. Hence, it could be considered as a potential modulatory compound in improving the patient's inflammatory condition.

中文翻译:

纳米姜黄素对轻度和重度COVID-19患者Th17细胞反应的免疫调节作用

在2019年新型冠状病毒疾病(COVID-19)中,T辅助(Th)17细胞的频率增加和过度活化以及随后产生大量促炎性细胞因子导致过度炎症和疾病进展。当前的研究旨在研究纳米姜黄素对轻度和重度COVID-19患者Th17细胞频率和反应的治疗作用。在这项研究中,纳入了40例重度COVID-19重症监护病房允许的患者和40例轻度患者。Th17细胞的频率,Th17细胞相关因子(RAR相关孤儿受体γt,白介素[IL] -17,IL-21,IL-23和粒细胞巨噬细胞集落刺激因子)的信使RNA表达,以及纳米姜黄素和安慰剂治疗组在治疗前后均测量了血清细胞因子水平。与安慰剂组相比,接受纳米姜黄素治疗的轻度和重度COVID-19患者的Th17细胞数量显着减少,Th17细胞相关因子的下调以及Th17细胞相关细胞因子的水平降低。此外,纳米姜黄素治疗组与治疗前相比,上述参数明显降低。姜黄素可以降低轻度和重度COVID-19患者的Th17细胞及其相关炎症因子的频率。因此,可以认为它是改善患者炎症状况的潜在调节化合物。与安慰剂组相比,用纳米姜黄素治疗的轻度和重度COVID-19患者中Th17细胞相关细胞因子水平降低。此外,纳米姜黄素治疗组与治疗前相比,上述参数明显降低。姜黄素可以降低轻度和重度COVID-19患者的Th17细胞及其相关炎症因子的频率。因此,可以认为它是改善患者炎症状况的潜在调节化合物。与安慰剂组相比,用纳米姜黄素治疗的轻度和重度COVID-19患者中Th17细胞相关细胞因子水平降低。此外,纳米姜黄素治疗组与治疗前相比,上述参数明显降低。姜黄素可以降低轻度和重度COVID-19患者的Th17细胞及其相关炎症因子的频率。因此,可以认为它是改善患者炎症状况的潜在调节化合物。姜黄素可以降低轻度和重度COVID-19患者的Th17细胞及其相关炎症因子的频率。因此,可以认为它是改善患者炎症状况的潜在调节化合物。姜黄素可以降低轻度和重度COVID-19患者的Th17细胞及其相关炎症因子的频率。因此,可以认为它是改善患者炎症状况的潜在调节化合物。
更新日期:2020-12-28
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