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Individual baseline behavioral traits predict the resilience phenotype after chronic social defeat
Neurobiology of Stress ( IF 5 ) Pub Date : 2020-12-29 , DOI: 10.1016/j.ynstr.2020.100290
Marija Milic , Ulrich Schmitt , Beat Lutz , Marianne B. Müller

Chronic social defeat (CSD) has been widely used as a psychosocial stress model in mice, with the magnitude of CSD-induced social avoidance as the major behavioral hallmark of the resilient and susceptible groups. Despite significant progress in the study of the neurobiology of resilient and susceptible mice, the nature and ethological relevance of CSD-induced social avoidance and social approach, particularly measured using a CD1 mouse, needs conceptual clarification. Based on the findings of a recent study revealing substantial individuality in genetically homogeneous inbred mice, we investigated whether certain baseline individual characteristics of male C57BL/6J mice predict the resilient outcome after CSD. We focused on two well-studied individual traits that seem to have heritable underpinnings—approach to novelty and avoidance of harm, which are essential for the expression of the exploratory drive. Our results showed that the exploration levels and the approach to novelty and harm were different before and after CSD in resilient and susceptible mice. Before the stress, resilient mice had higher horizontal activity in a novel environment, shorter approach latencies, and higher exploration times for social and non-social targets than susceptible mice. However, susceptible mice performed better in the passive avoidance task than resilient mice as they were more successful in learning to avoid potential adversity by suppressing the spontaneous exploratory drive. Our findings challenge the validity of the current selection criteria for the susceptible and resilient groups and encourage comprehensive assessment of both baseline and stress-induced individual behavioral signatures of mice.



中文翻译:

个体基线行为特征预测慢性社交失败后的复原力表型

慢性社交失败(CSD)已被广泛用作小鼠的心理应激模型,CSD引起的社交回避的程度是有弹性和易感人群的主要行为特征。尽管在有韧性和易感性小鼠的神经生物学研究方面取得了重大进展,但CSD诱发的社会回避和社会态度的性质和与道德相关性(特别是使用CD1小鼠进行测量)仍需要概念上的澄清。基于最近一项研究的发现,该研究揭示了遗传上同质的近交小鼠的显着个性,我们调查了雄性C57BL / 6J小鼠的某些基线个体特征是否可预测CSD后的弹性结果。我们专注于两个经过仔细研究的个人特征,它们似乎具有可遗传的基础-新颖性和避免伤害的方法,这对于探索性驱动的表达至关重要。我们的研究结果表明,在有韧性和易感性的小鼠中,CSD前后的探索水平以及对新颖性和伤害的处理方法是不同的。在承受压力之前,与易感小鼠相比,有弹性的小鼠在新颖的环境中具有较高的水平活动性,更短的进场等待时间以及对社交和非社交目标的探索时间更长。但是,易感小鼠在被动回避任务中的表现要好于有弹性的小鼠,因为它们通过抑制自发的探索性驱动力在学习避免潜在的逆境方面更加成功。

更新日期:2020-12-31
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