当前位置: X-MOL 学术React. Funct. Polym. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications
Reactive & Functional Polymers ( IF 5.1 ) Pub Date : 2020-12-29 , DOI: 10.1016/j.reactfunctpolym.2020.104808
Ana S. Ribeiro , Sofia M. Costa , Diana P. Ferreira , Ricardo C. Calhelha , Lillian Barros , Dejan Stojković , Marina Soković , Isabel C.F.R. Ferreira , Raul Fangueiro

The combination of biodegradable fibers at nanoscale with plant-based extracts is attracting increasing attention to produce wound dressing systems. In this work, nanofibers based on chitosan (CS), poly(ethylene oxide) (PEO), cellulose nanocrystals (CNC) and acacia plant-based extract were developed by electrospinning. Firstly, the polymeric formulations and electrospinning parameters were optimized, resulting in nanofibers with average diameters of 80 nm. CNC were successfully introduced into the optimized CS/PEO blend and the membranes were characterized by FESEM, ATR-FTIR, TGA, XRD, WVTR and WCA. The CNC incorporation improved the nanofibers' physical integrity, morphology, diameters, water vapor transmission rate and thermal properties. After acacia introduction into the best CS/PEO/CNC system, the antibacterial effect was relatively maintained while the antifungal activity was enhanced for some fungi, demonstrating its great effect against a wide range of microorganisms, which is crucial to prevent or treat infections. All the developed systems exhibited absence of cytotoxicity in non-tumor cells, suggesting their biocompatibility. Finally, a continuous release of the acacia extract was observed for 24 h, showing its prolonged action, which contributes to the healing process while reduces the frequency of dressing's replacement. Overall, the developed nanofibers are very promising to act as localized drug delivery systems for wound care applications.



中文翻译:

具有增强的抗菌和抗真菌活性的壳聚糖/纳米纤维素电纺纤维,用于伤口包扎应用

纳米级可生物降解纤维与植物提取物的结合正日益引起人们对生产伤口敷料系统的关注。在这项工作中,通过静电纺丝开发了基于壳聚糖(CS),聚环氧乙烷(PEO),纤维素纳米晶体(CNC)和阿拉伯胶植物提取物的纳米纤维。首先,优化聚合物配方和静电纺丝参数,得到平均直径为80 nm的纳米纤维。将CNC成功地引入到优化的CS / PEO共混物中,并通过FESEM,ATR-FTIR,TGA,XRD,WVTR和WCA对膜进行了表征。CNC合并提高了纳米纤维的物理完整性,形态,直径,水蒸气透过率和热性能。将阿拉伯胶引入最佳的CS / PEO / CNC系统后,相对的抗菌作用得以保持,同时某些真菌的抗真菌活性得到增强,表明其对多种微生物的巨大作用,这对于预防或治疗感染至关重要。所有已开发的系统在非肿瘤细胞中均未显示出细胞毒性,表明它们具有生物相容性。最后,观察到金合欢提取物连续释放24小时,显示出其延长的作用,这有助于愈合过程,同时减少了敷料的更换频率。总体而言,开发的纳米纤维非常有望用作伤口护理应用中的局部药物输送系统。所有已开发的系统在非肿瘤细胞中均未显示出细胞毒性,表明它们具有生物相容性。最后,观察到阿拉伯胶提取物连续释放24小时,显示其作用延长,这有助于愈合过程,同时减少了敷料的更换频率。总体而言,开发的纳米纤维非常有望用作伤口护理应用中的局部药物输送系统。所有已开发的系统在非肿瘤细胞中均未显示出细胞毒性,表明它们具有生物相容性。最后,观察到阿拉伯胶提取物连续释放24小时,显示其作用延长,这有助于愈合过程,同时减少了敷料的更换频率。总体而言,开发的纳米纤维非常有望用作伤口护理应用中的局部药物输送系统。

更新日期:2021-01-04
down
wechat
bug