During the synthesis of new structural analogs of isothiobarbamine, the amidoalkylation of 6-hydroxy-5-isopropyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one was found to give a mixture of mono-, di-, and trisubstituted products. Possible explanations for low regioselectivity of the reaction are given.

中文翻译：

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6-羟基-5-异丙基-2-硫代-2,3-二氢嘧啶-4(1H)-one酰胺烷基化的特性

在异硫巴胺的新结构类似物的合成过程中，发现 6-羟基-5-异丙基-2-硫代-2,3-二氢嘧啶-4(1H)-one 的酰胺烷基化得到单-、二-、和三取代产品。给出了反应的低区域选择性的可能解释。