Naturally occurring naphthoquinones (NQs) comprising highly reactive small molecules are the subject of increasing attention due to their promising biological activities such as antioxidant, antimicrobial, apoptosis-inducing activities, and especially anticancer activity. Lapachol, lapachone, and napabucasin belong to the NQs and are in phase II clinical trials for the treatment of many cancers. This review aims to provide a comprehensive and updated overview on the biological activities of several new NQs isolated from different species of plants reported from January 2013 to January 2020, their potential therapeutic applications and their clinical significance.

天然的包含高反应性小分子的萘醌（NQs）由于其有希望的生物学活性，例如抗氧化剂，抗微生物剂，诱导细胞凋亡的活性，特别是抗癌活性而受到越来越多的关注。Lapachol，lapachone和napabucasin属于NQ，目前处于II期临床试验中，用于治疗多种癌症。这篇综述旨在提供有关2013年1月至2020年1月报告的从不同植物物种中分离出来的几种新NQ的生物学活性，其潜在治疗应用及其临床意义的全面更新的概述。